Effect of some anti-inflammatory drugs on the corrosion behavior of implant biomaterials in human body fluid

Abstract EN

The aim of this research is to compare the electrochemical behavior of two surgical implant biomaterials alloys, SS 316L and Co–Cr–Mo alloy in simulated body fluid.

This comparison is focused on the influence of presence of three anti-inflammatory drugs, aspirin (C9H8O4), paracetamol (C8H9NO2), and mefenamic acid (C15H15NO2) with three concentrations of each drug (0.00303, 0.00606, and 0.01212), (0.0086, 0.0172, and 0,0344), and (0.00111, 0.00156, and 0.00201) g / 300ml respectively at pH = 7.4 and 37oC using electrochemical techniques, potentiodynamic curves and potentiostatic tests.

Influence of these drugs on both biomaterials depends on the formation of organometallic complexes between released metals ions from implant alloys and drugs molecules.

The study shows that the drugs behave as inhibitors for SS 316L through the measured corrosion parameters, while gives irregular behavior in the case of Co – Cr –Mo alloy.

However, difference between two alloys appear with different affinity of released metal ions to binding with other molecules inside human body.