A zeolite promoted synthesis and antibacterial activity of novel thiazolidinone derivatives of some sulphonamide schiff’s bases

Abstract EN

In the present paper, we have executed the synthesis of substituted 4-(2-(2- chloroquinoline-3-yl)-4-oxothiazolidin-3-yl)-N-phenyl benzene sulphonamide via the reactions of substituted 4-((2-chloroquinoline-3-yl) methylene amino)-N- phenyl benzene sulphonamide with thioglycolic acid and zeolite 78-88 % yields at 110 oC under microwave irradiation.

This method provides several advantages such as operational simplicity, higher yield, safety and environment friendly protocol.

The resulting substituted sulphonamide derivatives were characterized on the basis of 1H NMR, 13C NMR, I.R, elemental analysis, and mass spectral data.