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Spectrophotometric determination of oxymetazoline hydrochloride based on the oxidation reactions
Joint Authors
al-Sabha, Theiaa N.
Rashid, Bassam A.
Source
Issue
Vol. 6, Issue 4 (31 Dec. 2011), pp.403-411, 9 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2011-12-31
Country of Publication
Jordan
No. of Pages
9
Main Subjects
Topics
Abstract EN
Simple, sensitive and reproducible spectrophotometric method was developed for determination of oxymetazoline hydrochloride in pure as well as in pharmaceutical drop formulations.
The method is based on the reduction of ferric to ferrous ions followed by complexation with 1,10-phenanthroline to produce an orange red chromogen that has maximum absorption at 510 nm and obeyed Beer’s linearity in the concentration range of 0.1-7 μg / ml, with molar absorptivity 5.74 ×104 l.mol-1cm-1, accuracy (average recovery %) 100.53 % and precision better than 1.
6.
The developed method was successfully applied to the determination of oxymetazoline hydrochloride in bulk and pharmaceutical formulations without any interference from common excipients.
American Psychological Association (APA)
al-Sabha, Theiaa N.& Rashid, Bassam A.. 2011. Spectrophotometric determination of oxymetazoline hydrochloride based on the oxidation reactions. Jordan Journal of Chemistry،Vol. 6, no. 4, pp.403-411.
https://search.emarefa.net/detail/BIM-297350
Modern Language Association (MLA)
al-Sabha, Theiaa N.& Rashid, Bassam A.. Spectrophotometric determination of oxymetazoline hydrochloride based on the oxidation reactions. Jordan Journal of Chemistry Vol. 6, no. 4 (Dec. 2011), pp.403-411.
https://search.emarefa.net/detail/BIM-297350
American Medical Association (AMA)
al-Sabha, Theiaa N.& Rashid, Bassam A.. Spectrophotometric determination of oxymetazoline hydrochloride based on the oxidation reactions. Jordan Journal of Chemistry. 2011. Vol. 6, no. 4, pp.403-411.
https://search.emarefa.net/detail/BIM-297350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 411
Record ID
BIM-297350