Spectrophotometric methods for the determination of nimodipine in pure and in pharmaceutical preparations
Joint Authors
Mallegowda, Shiramahally M.
Deepakumari, Hemavathi N.
Vinay, Kanakapura B.
Source
Issue
Vol. 6, Issue 4 (31 Dec. 2011), pp.413-422, 10 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2011-12-31
Country of Publication
Jordan
No. of Pages
10
Main Subjects
Topics
Abstract EN
Four simple, sensitive, accurate and rapid visible spectrophotometric methods (A, B, C and D) have been developed for the estimation of nimodipine in both in pure and pharmaceutical preparations.
They are based on the diazotization of reduced nimodipine with nitrous acid followed by coupling with acetylacetone (Method A), diphenylamine (Method B), citrazinic acid (Method C) and chromotropic acid (Method D) to form respective colored azo-dyes and exhibiting absorption maxima (λmax) at 420, 540, 440 and 520 nm, respectively.
The colored azodyes formed are stable for more than 2h.
Beer's law was obeyed in the concentration range of 0-35, 0-25, 0-35 and 0-35 μg / mL for methods A, B, C and D, respectively.
The results of the four analyses have been validated statistically and by recovery studies.
The results obtained in the proposed methods are in good agreements with labeled amounts, when marketed pharmaceutical preparations are analyzed.
American Psychological Association (APA)
Mallegowda, Shiramahally M.& Deepakumari, Hemavathi N.& Vinay, Kanakapura B.. 2011. Spectrophotometric methods for the determination of nimodipine in pure and in pharmaceutical preparations. Jordan Journal of Chemistry،Vol. 6, no. 4, pp.413-422.
https://search.emarefa.net/detail/BIM-297352
Modern Language Association (MLA)
Mallegowda, Shiramahally M.…[et al.]. Spectrophotometric methods for the determination of nimodipine in pure and in pharmaceutical preparations. Jordan Journal of Chemistry Vol. 6, no. 4 (Dec. 2011), pp.413-422.
https://search.emarefa.net/detail/BIM-297352
American Medical Association (AMA)
Mallegowda, Shiramahally M.& Deepakumari, Hemavathi N.& Vinay, Kanakapura B.. Spectrophotometric methods for the determination of nimodipine in pure and in pharmaceutical preparations. Jordan Journal of Chemistry. 2011. Vol. 6, no. 4, pp.413-422.
https://search.emarefa.net/detail/BIM-297352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 422
Record ID
BIM-297352