Effect of treatment with omega-3 fatty acids on C - reactive protein and tumor necrosis factor-alfa in hemodialysis patients
Joint Authors
Tayyebi-Khosroshahi, Hamid
Houshyar, Jalil
Dehgan-Hesari, Rida
Alikhah, Husayn
Safaeian, Abd al-Rasul
Zonouz, Nada Rizqi
Vatankhah, Amir Mansur
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 23, Issue 3 (30 Jun. 2012), pp.500-506, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2012-06-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
C-reactive protein (CRP), a strong independent risk marker of cardiovascular disease (CVD), and tumor necrosis factor-alfa (TNF-α), a known pro-inflammatory cytokine, are elevated and have damaging effects in patients with chronic renal failure (CRF).
Omega-3 fatty acids play an important modulatory role in inflammatory responses.
The aim of this study is to review the alterations in serum levels of TNF-α, CRP and other parameters caused by omega-3 supplementation in dialysis patients.
The clinical trial was performed in 37 patients with end-stage renal disease undergoing dialysis in hemodialysis centers of three university hospitals in Tabriz.
Blood samples were obtained from the study patients for hemoglobin, albumin, ferritin, triglyceride, total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL)- cholesterol, TNF-α and high specific-CRP (hs-CRP) measurement.
The patients received 3 g omega-3 per day for 2 months.
The side-effects noticed were nausea, diarrhea and dyspepsia and undesired drug smell.
The difference noted in hemoglobin, albumin, ferritin, CRP, triglyceride, total, LDL and HDL-cholesterol before and after supplementation with omega-3 fatty acid was not statistically significant (P > 0.05).
However, the use of omega-3 decreased the serum levels of TNF-α significantly.
We conclude that the use of 3 g of omega-3 per day caused significant decrease in serum levels of TNF-α in the dialysis population, and its use is recommended in such patients.
American Psychological Association (APA)
Tayyebi-Khosroshahi, Hamid& Houshyar, Jalil& Dehgan-Hesari, Rida& Alikhah, Husayn& Safaeian, Abd al-Rasul& Zonouz, Nada Rizqi…[et al.]. 2012. Effect of treatment with omega-3 fatty acids on C - reactive protein and tumor necrosis factor-alfa in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 3, pp.500-506.
https://search.emarefa.net/detail/BIM-297459
Modern Language Association (MLA)
Safaeian, Abd al-Rasul…[et al.]. Effect of treatment with omega-3 fatty acids on C - reactive protein and tumor necrosis factor-alfa in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 3 (Jun. 2012), pp.500-506.
https://search.emarefa.net/detail/BIM-297459
American Medical Association (AMA)
Tayyebi-Khosroshahi, Hamid& Houshyar, Jalil& Dehgan-Hesari, Rida& Alikhah, Husayn& Safaeian, Abd al-Rasul& Zonouz, Nada Rizqi…[et al.]. Effect of treatment with omega-3 fatty acids on C - reactive protein and tumor necrosis factor-alfa in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 3, pp.500-506.
https://search.emarefa.net/detail/BIM-297459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 504-506
Record ID
BIM-297459