Protective role of omega-3 fish oil against the toxicity of ifosfamide in male rats
Joint Authors
Source
Jordan Journal of Biological Sciences
Issue
Vol. 5, Issue 1 (31 Mar. 2012), pp.37-46, 10 p.
Publisher
The Hashemite University Deanship of Academic Research and Graduate
Publication Date
2012-03-31
Country of Publication
Jordan
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract EN
Ifosfamide IFO) is a cytotoxic alkylating drug used for the treatment of a variety of cancers but has reported to cause certain hematological, hepatotoxic and nephrotoxic side effects.
For protection against these side effects, different antioxidants were used.
This study is performed to evaluate the ability of omega-3 fatty acids (Omega-3 FAs) to attenuate ifosfamide (IFO) toxicity.
Thirty male albino rats were randomly divided into six groups.
Group 1: control, Group 2: omega-3 (4gm / kg diet), Group 3 : IFO (50mg / kg b.
wt.), Group 4: IFO (80mg / kg b.
wt.), Group 5 : IFO (50mg / kg b.
wt.) plus omega-3, Group 6: IFO (80mg / kg b.
wt.) plus omega-3.
Ifosfamide was administrated intraperitoneally (i.
p.), while omega-3 was given with the diet.
The duration was five consecutive days for IFO, and six consecutive days for omega-3 oil.
A significant increase in the body weight gain of the rats has been recorded after applying omega-3 to both doses of IFO when compared to each IFO group.
In the IFO group, the levels of serum creatinine, phosphorous, glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT) and malondialdehyde (MDA) were increased, while serum glucose decreased significantly.
In the Omega-3 and IFO plus omega-3 groups, these variations didn’t show significant changes.
Hematologically, Omega-3 has recovered the decrease in WBC, RBC and blood platelets caused by IFO after giving omega-3 to the IFO treated rats.
IFO has induced many histological alterations in the liver such as degeneration of the cells, inflammatory cells infiltration and dilation in the sinusoidal lumen, while it caused severe inflammation, degeneration in the kidney tubule lining cells and hypertrophy of these tubules.
The histological structure of liver and kidney was found to be protected from this effect of IFO when a combination of Omega-3 FAs and IFO was administrated.
Interestingly, Omega-3 didn’t interfere with the antimitotic property of IFO, suggesting a very important role of this oil in the future of cancer chemotherapy.
American Psychological Association (APA)
Asaad, Hiwa R.& Aziz, Falah M.. 2012. Protective role of omega-3 fish oil against the toxicity of ifosfamide in male rats. Jordan Journal of Biological Sciences،Vol. 5, no. 1, pp.37-46.
https://search.emarefa.net/detail/BIM-297934
Modern Language Association (MLA)
Asaad, Hiwa R.& Aziz, Falah M.. Protective role of omega-3 fish oil against the toxicity of ifosfamide in male rats. Jordan Journal of Biological Sciences Vol. 5, no. 1 (Mar. 2012), pp.37-46.
https://search.emarefa.net/detail/BIM-297934
American Medical Association (AMA)
Asaad, Hiwa R.& Aziz, Falah M.. Protective role of omega-3 fish oil against the toxicity of ifosfamide in male rats. Jordan Journal of Biological Sciences. 2012. Vol. 5, no. 1, pp.37-46.
https://search.emarefa.net/detail/BIM-297934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 44-46
Record ID
BIM-297934