Antinociceptive effects of Melisa officinal is aerial parts extracts in mice

Abstract EN

Background : Some labiatae family plants show antinociceptive activities.

Melisa officinalis belongs to this family, thus antinociceptive activity of the aqueous decoction and ethanolic maceration extracts of the aerial parts of this plant studied in mice. Results : Antinociceptive activities were done using hot-plate and writhing tests.

In hot-plate and writhing tests, the intraperitoneal injection of both extracts showed significant antinociceptive activity in mice.

Naloxone, an opioid antagonist, pre-treatment, inhibited the antinociceptive activity of the extracts in hot-plate test.

The extracts exhibited antinoceceptive activity against acetic acid induced writhing which was partially blocked by naloxone. Conclusion : It is concluded that the aqueous decoction and ethanolic maceration of the aerial parts of M.

officinalis has antinociceptive effects and this may be mediated partially by opioid receptors.