Correlation between HLA system and primary vesicoureteral reflux

Abstract EN

Objectives : The polygenic mode for inheritance of Vesicoureteral Reflux (VUR) is a debutable issue.

Our study is aimed to investigate the correlation between HLA system and VUR. Materials : The study included thirty patients with VUR and sixty patients from kidney donors as control group.

Initially the HLA formulas of each patient were detected according to racialgeographical distribution as well as common and specific antigens.

Then, the Relative Risk (RR) for the class I antigens of the HLA system was calculated and the X2 statistical test was performed for the antigens with RR>1 to establish a significant association between HLA system and VUR. Results : Increased frequency of the genes HLA-A9, HLA-B44 were characterized by statistical analysis (RR > 1, X2 > 3.84).

Therefore, the significant correlation was found between VUR and HLA system (P < 0.05). Conclusion : There are significant correlation between VUR and HLA-A9 and HLA-B44.

However, more study is necessary that these genes may become markers for VUR.