Assessment of some coagulation parameters in GI bleeding patients in a sudanese center for GI.

Abstract EN

This study was conducted at Mohammed Salih Idres Center for gastrointestinal bleeding at Khartoum, Sudan.

Prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet count were measured in 50 gastrointestinal bleeding patients (43 males (86%) and 7 females (14%) with a mean age of 47 years) compared to corresponding parameters in 30 healthy individuals used as a control group.

Blood samples were analyzed to determine the effect of GI bleeding on coagulation and correlate coagulation parameters investigated to age, gender and causes of GI bleeding.

The results obtained showed that PT and APTT were significantly prolonged in patients than in control (P=0.00), while platelets count was significantly decreased in patients than in control (P=0.00).

The results also indicated that, patients of GI bleeding due to esophageal varices (OV) were of higher prevalence but with normal coagulation pathways and platelets count.

Furthermore, patients with portal hypertension (PHT) have been found to have a decreased platelets count.

The results of the present work concluded that, patients with other causes of GIT bleeding found to have a defect in the intrinsic and extrinsic pathways associated with reduced platelet count.

Also this work concluded that no statistically significant correlation was found between coagulation parameters investigated and gender or age in the study population.

KEYWORDS; gastric bleeding, hemostatic parameters, coagulation disorders, PT and aPTT