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pleural mesothelioma : Diagnostic problems and evaluation of prognostic factors
Joint Authors
Abd al-Rahman, Abd al-Rahman M.
Ismail, Huda M.
Nuh, Muhammad Akram A.
Abu al-Khayr, Iman L.
Tawfiq, Hassan N.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 18, Issue 4 (31 Dec. 2006), pp.303-310, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2006-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Malignant pleural mesothelioma (MPM) in Egypt is mainly attributed to an environmental origin i.e exposure to asbestos, with a high incidence in women and young adults.
Immunohislochcmistry and ultraslruc-tural features aid in the diagnosis.
The p27Kipl is a kinase inhibitor protein acting as a cell cycle regulator and a putative tumor suppressor gene playing a critical role in the pathogenesis of several human neoplasms.
Aim : A clinicopathologic, immunohistochemical and ultrastruclural study of mesothelioma in Egyptian patients, with identification of different prognostic factors.
Material and Methods ; Sixty-one cases of MPM were collected from the department of pathology at the NCI, Cairo.
Cases were stained by monoclonal antibodies against CK.
5 / 6.
calretinin, vimentin, CD 15, CEAand p27.
Results : More than half (57.4 %) of the patients were residents in endemic areas; 50.8 % were of epithelioid type.
CK5 / 6 was positive in 45 (73.8 %) cases, 39 (63.9 %) cases were positive for vimentin, 49 (80.3 %) cases were positive for calretinin.
One case showed a focal weak positive reaction to CD15.
None of the cases stained for CEA.
There was a statistically significant relation between p27 expression and the histopathologic type (p = 0.02) between overall survival and age (p = 0.01), histopathologic type (p = 0.02) and stage (p = 0.006).
Conclusion : MPM is an increasing disaster in Egypt which is underestimated and neglected.
A panel of immu¬nohistochemical markers should be used for proper eval¬uation.
p27 has proven to be a potential biologic prognostic marker for mesothelioma and more studies as regard its significance arc recommended on a larger number.
American Psychological Association (APA)
Ismail, Huda M.& Abd al-Rahman, Abd al-Rahman M.& Nuh, Muhammad Akram A.& Abu al-Khayr, Iman L.& Tawfiq, Hassan N.. 2006. pleural mesothelioma : Diagnostic problems and evaluation of prognostic factors. Journal of the Egyptian National Cancer Institute،Vol. 18, no. 4, pp.303-310.
https://search.emarefa.net/detail/BIM-29864
Modern Language Association (MLA)
Ismail, Huda M.…[et al.]. pleural mesothelioma : Diagnostic problems and evaluation of prognostic factors. Journal of the Egyptian National Cancer Institute Vol. 18, no. 4 (Dec. 2006), pp.303-310.
https://search.emarefa.net/detail/BIM-29864
American Medical Association (AMA)
Ismail, Huda M.& Abd al-Rahman, Abd al-Rahman M.& Nuh, Muhammad Akram A.& Abu al-Khayr, Iman L.& Tawfiq, Hassan N.. pleural mesothelioma : Diagnostic problems and evaluation of prognostic factors. Journal of the Egyptian National Cancer Institute. 2006. Vol. 18, no. 4, pp.303-310.
https://search.emarefa.net/detail/BIM-29864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references: p p. 309-310
Record ID
BIM-29864