Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters
Joint Authors
Qandil, Muna A.
Abd al-Wahid, Mushirah M.
Samaka, Rehab M.
Abduh, Asmaa G.
al-Kady, Nuha M.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 18, Issue 4 (31 Dec. 2006), pp.363-374, 12 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2006-12-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Background : Cyclooxygenase-2 (Cox-2) is the induc-ible form of cyclooxygenase enzyme.
Cox-2 is induced in numerous processes such as cellular growth, differen-tiation, inflammation and tumorogencsis.
Purpose : Assessment of Cox-2 expression in chronic gastritis and gastric carcinoma.
Material and Methods : Sixteen chronic gastritis (CG) and 43 gastric carcinoma cases were subjected to an immunohistoehemical approach using anti Cox-2 antibody.
Results : All CG cases displayed positive epithelial Cox-2 expression with only 25 % positivity for stromal expression.
Eighty six percent of gastric carcinoma showed epithelial Cox-2 expression that was significantly correlated with lymph node involvement (p = 0.0l), advanced stage p = 0.01), high microvessel density (MVD) (p = 0.0001), vascular invasion (p = 0.002), perineural invasion (p = 0.01) and low apoptolic count (p < 0.0001).
Stromal Cox-2 ex¬pression was seen in 79 % of gastric carcinoma cases and was significantly associated with low apoptotic count (p=0.0007), vascular invasion (P = 0.001) and high mi¬crovessel density (MVD) (p = 0.0003).
Only stromal Cox-2 expression was significantly higher in gastric carcinoma than chronic gastritis (p = 0.0001).
Conclusions : Cox-2 appears to be involved in gastric carcinoma progression as it promotes angiogencsis, sup-presses apoptosis and facilitates invasion and metastasis.
Double expression of Cox-2 in gastric carcinoma epithe-lium and stroma and significant association between them demonstrate a paracrine cross effect between stromal and malignant epithelium.
American Psychological Association (APA)
Samaka, Rehab M.& Abduh, Asmaa G.& Abd al-Wahid, Mushirah M.& Qandil, Muna A.& al-Kady, Nuha M.. 2006. Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters. Journal of the Egyptian National Cancer Institute،Vol. 18, no. 4, pp.363-374.
https://search.emarefa.net/detail/BIM-29901
Modern Language Association (MLA)
Samaka, Rehab M.…[et al.]. Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters. Journal of the Egyptian National Cancer Institute Vol. 18, no. 4 (Dec. 2006), pp.363-374.
https://search.emarefa.net/detail/BIM-29901
American Medical Association (AMA)
Samaka, Rehab M.& Abduh, Asmaa G.& Abd al-Wahid, Mushirah M.& Qandil, Muna A.& al-Kady, Nuha M.. Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters. Journal of the Egyptian National Cancer Institute. 2006. Vol. 18, no. 4, pp.363-374.
https://search.emarefa.net/detail/BIM-29901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : pp. 372-374
Record ID
BIM-29901