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Role of radio-iodinated meta-iodo benzyl guanidine in assessment of children with neuroblastoma at nemrock
Other Title(s)
دور ( radio-iodinated meta-iodo benzyl guanidine) في تقييم الأطفال المصابين بالورم الأرومي العصبي في نيمروق
Author
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 18, Issue 4 (31 Dec. 2006), pp.375-381, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2006-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : For more than ten years.
MIBG has been successfully used in diagnosis and staging of children with neuroblastoma [1].
Aim of the Study : Identify the role of 131I MIBG in the assessment of neuroblastoma and correlate its findings with other non-invasive tests.
Patients and Methods : Twenty eight patients with neuroblastoma attending the Pediatric Oncology Unit, Kasr El-Aini Center of Radiation Oncology and Nuclear Medicine (NEMROCK), Cairo University, over a period of 5 years (2002-2006) were assessed by MIBG scanning.
The age of patients ranged from 40 days to 12 years with a mean of 4.7years ± 1.1.
They were 16 boys and 12 girls with a M:F ratio of 1 : 3, none was stage I and II, 7 patients (25 %) were stage III and 21 patients (75 %) were stage IV (Evan's staging system).
Clinically, 24 patients (85.7 %) presented with an abdominal mass, and 3 patients (10.7 %) with a mediastinal mass.
Metastases were present in the bone marrow in 11 children (39.3 %), lymph nodes in 5 (17.9 %), CNS in 4 (14.3 %), liver in 2 (7.1 %), soft tissues in 3 (10.7 %), lungs and pleura in 1 (3.6 %), brain in 1 (3.6 %), and testis in 1 patient (3.8 %).
Results : 131I MIBG could accurately diagnose local and distant neuroblastoma lesions in 23 patients with a sensitivity of 82.2 %.
High levels of VMA correlated with no cardiac uptake in the first 24 hours in 7 / 8 patients with a sensitivity of 87.5 %.
On the other hand, low VMA levels were associated with cardiac uptake of 1311 MIBG in 3 / 4 patients with a specificity of 75 %, a PPV of 88 % and NPV of 86.7 %.
1311 MIBG scintigraphy and bone marrow aspiration agreed on detecting neuroblastoma lesions in 24 / 28 patients (85.7 %) p < 0.01, with a sensitivity of 59.5 %, specificity of 96.6 %.
PPV of 89.3 %, and NPV of 83.2 %.
Conclusion : 131I MIBG scintigraphy, in a dose of 2 mci can be used with 87.5 % accuracy in the diagnosis and follow-up of Children with neuroblastoma.
American Psychological Association (APA)
Abd al-Al, Hisham H.. 2006. Role of radio-iodinated meta-iodo benzyl guanidine in assessment of children with neuroblastoma at nemrock. Journal of the Egyptian National Cancer Institute،Vol. 18, no. 4, pp.375-381.
https://search.emarefa.net/detail/BIM-29920
Modern Language Association (MLA)
Abd al-Al, Hisham H.. Role of radio-iodinated meta-iodo benzyl guanidine in assessment of children with neuroblastoma at nemrock. Journal of the Egyptian National Cancer Institute Vol. 18, no. 4 (Dec. 2006), pp.375-381.
https://search.emarefa.net/detail/BIM-29920
American Medical Association (AMA)
Abd al-Al, Hisham H.. Role of radio-iodinated meta-iodo benzyl guanidine in assessment of children with neuroblastoma at nemrock. Journal of the Egyptian National Cancer Institute. 2006. Vol. 18, no. 4, pp.375-381.
https://search.emarefa.net/detail/BIM-29920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : pp. 380-381
Record ID
BIM-29920