Serum zinc and copper level before and after haemodialysis

Abstract EN

Background : Zinc and Copper are those trace elements which are necessary for human growth and biological functions.

Concentration changes of these elements in the body are clinically important.

This research has been set up to study the possibility of zinc and copper variations after haemodialysis, and to determine the serum zinc and copper concentrations before and after heamodialysis. Methods : This project is a comparative, non-experimental study.

The sample population was 50 of haemodialized patients chosen randomly from the patients referred to Azar hospital in Gorgan in the year of 2003 (33 male and 17 female).

The concentration of serum urea, creatinine, and copper of these patients were determined before and after dialysis, and were analyzed by SPSS software suing the Wilkacson tests. Results : The results of this research indicates that the average concentration of zinc and copper in haemodialized patients after dialysis were 135.32 59.32 and 136.40 51.25 microgram/deci litre respectively which is markedly increased in comparison to the serum concentrations of these trace elements before dialysis which were 78.38 37.46 and 89.92 32.54 microgram/deci litre respectively. Conclusion : In this study the average increase in concentration of zinc and copper after the process of dialysis among the haemodialized patients had a meaningful statistical variation (P < 0.001).

Uremia, quality of dialysis membrane and quality of water used for the process of dialysis could be a reason for increase in concentration of zinc and copper.