Hepatoprotective effect of camel urine against carbon tetrachloride induced hepatotoxicity in rats

Abstract EN

Oral administration to rats of 4ml/100g body weight (B.W.) of 24 hour adult she-camel urine (24 HCU) and 2ml/100g BW of young she-camel early morning urine (EMU); one hour before carbon tetrachloride (CCl4) injection resulted in reduced mortality to 0 and 40% respectively.

8 ml of the (24HCU) were lethal to rats in less than 55 minutes following oral administration.

Different doses of the above camel urine and the latter chloroformic extract were assessed for their effect on rat liver transaminases activities.

Reduction of the high activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) induced by CCL4 and the amelioration of the liver hepatotoxicity were noticed after the administration of 4ml, 2ml and 0.2ml respectively.

A linear decrease of ALT activity with double dosing female camel urine chloroformic extract (CE) was observed and addition of these components one hour after CCL4 administration gave the same results.

These results indicated that, camel urine, as crude or chloroformic extract played an important role as an antioxidant and efficiently acted as a protective agent against liver damage.

KEY WORDS: Hepatotxeiaty, camel, urine, hepatoprotative effect.