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A panel of molecular markers in hepatitis c virus-related hepatocellular carcinoma
Joint Authors
Husayn, Muhammad
al-Attar, Inas
al-Jundi, Sad M.
al-Shirbini, Mamduh M.
Abd al-Salam, Ibrahim M.
al-Asser, Abd al-Basit A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 17, Issue 4 (31 Dec. 2005), pp.270-278, 9 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2005-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Background : Hepatocellular carcinoma is triggered by many factors including infection with hepatitis C virus.
The molecular basis, however, of the development of HCV-related HCC remains unknown.
Objective : This work was designated to compare the circulating levels of some molecular markers between HCV-infected and HCV-free HCC patients.
Methods : We investigated 77 of HCC patients admitted to the National Cancer Institute, Cairo during the period 2002-2003.
The plasma circulating levels of bcl-2, transforming growth factor beta 1 (TGF-ß1), vascular endothelial growth factor (VEGF) and beta2-microglobulin (ß2- MG) were investigated in HCV related HCC patients (n = 40) compared to both HCV-free HCC patients (n = 37) and a group of healthy subjects (n = 20).
Additionally, the LOH at the mannose 6-phosphate / insulin like growth factor-II receptor (M6P / IGFIIr) was investigated.
Results : The result did not predict a significant role of HCV infection on the circulating bcl-2 protein.
In both HCC and HCC / HCV groups a limited number of patients had high levels of bcl-2.
TGF-ß1 level increased particularly, but insignificantly in HCC associated with HCV infection.
A similar pattern was obtained in the levels of ß2-MG, however the difference between HCC and HCC / HCV patients was significant (p = 0.001).
The infection with HCV was associated with a high incidence of LOH at M6P / IGFIIr site compared to HCV-free patients.
Although the level of serum VEGF was significantly higher in all HCC patients than in healthy control, no significant difference, however was observed between HCV infected and HCV-free groups.
Conclusion : In HCC patients, HCV infection did not exclusively affect the levels of both bcl-2 and VEGF.
TGF-ß1, ß2-MG and the LOH at M6P/IGFIIr, however were higher in presence of HCV infection.
American Psychological Association (APA)
al-Jundi, Sad M.& Husayn, Muhammad& al-Shirbini, Mamduh M.& Abd al-Salam, Ibrahim M.& al-Attar, Inas& al-Asser, Abd al-Basit A.. 2005. A panel of molecular markers in hepatitis c virus-related hepatocellular carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 17, no. 4, pp.270-278.
https://search.emarefa.net/detail/BIM-29985
Modern Language Association (MLA)
al-Jundi, Sad M.…[et al.]. A panel of molecular markers in hepatitis c virus-related hepatocellular carcinoma. Journal of the Egyptian National Cancer Institute Vol. 17, no. 4 (Dec. 2005), pp.270-278.
https://search.emarefa.net/detail/BIM-29985
American Medical Association (AMA)
al-Jundi, Sad M.& Husayn, Muhammad& al-Shirbini, Mamduh M.& Abd al-Salam, Ibrahim M.& al-Attar, Inas& al-Asser, Abd al-Basit A.. A panel of molecular markers in hepatitis c virus-related hepatocellular carcinoma. Journal of the Egyptian National Cancer Institute. 2005. Vol. 17, no. 4, pp.270-278.
https://search.emarefa.net/detail/BIM-29985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical teferences : p. 277-278
Record ID
BIM-29985