![](/images/graphics-bg.png)
Double masked randomized clinical trial comparing latanoprost with timolol in open angle glaucoma
Joint Authors
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 7, Issue 3 (31 Jan. 2005), pp.21-26, 6 p.
Publisher
Publication Date
2005-01-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Objectives : To Compare the efficacy and safety of latanoprost once a day with timolol administered twice a day in patients with open angle glaucoma.
Methods : In this six month double masked randomized clinical trial, 80 patients with primary open angle glaucoma were divided randomly for treatment to either 0.005% latanoprost once a day (n = 40) or 0.5% timolol twice a day (n = 40).
Intraocular pressure was measured, and efficacy was based on intraocular pressure reduction from baseline.
Results: Through the day the mean IOP was significantly lower with latanoprost than with timolol.
Diurnal IOP (10 : 00 AM , 4 : 00 PM, 8 : 00 PM) was reduced from 26.2 to 16.9 mmHg with latanoprost and from 25.8 to 17.4 mmHg with timolol at the end of the 6-month treatment period.
Mean IOP reduction ranged from 7.8 to 8.2 mmHg in 35.2% of the latanoprost group and from 6.3 to 6.8 mmHg in 33.9% of the timolol group.
Significantly higher percentage of patients had low IOP levels with latanoprost than timolol (P < 0.001).The decrease from baseline IOP was up to 8.2 mmHg in latanoprost group compared to 6.2 mmHg in timolol group.
Latanoprost caused more conjunctival hyperemia than timolol.
Timolol caused more systemic side effects than latanoprost.
Conclusion : There were greater mean and peak IOP reductions achieved with 0.005% latanoprost QD compared with 0.5% timolol.
BID.
American Psychological Association (APA)
Shoja, M. R.& Maanaviat, M. R.. 2005. Double masked randomized clinical trial comparing latanoprost with timolol in open angle glaucoma. Iranian Red Crescent Medical Journal،Vol. 7, no. 3, pp.21-26.
https://search.emarefa.net/detail/BIM-29987
Modern Language Association (MLA)
Shoja, M. R.& Maanaviat, M. R.. Double masked randomized clinical trial comparing latanoprost with timolol in open angle glaucoma. Iranian Red Crescent Medical Journal Vol. 7, no. 3 (Jan. 2005), pp.21-26.
https://search.emarefa.net/detail/BIM-29987
American Medical Association (AMA)
Shoja, M. R.& Maanaviat, M. R.. Double masked randomized clinical trial comparing latanoprost with timolol in open angle glaucoma. Iranian Red Crescent Medical Journal. 2005. Vol. 7, no. 3, pp.21-26.
https://search.emarefa.net/detail/BIM-29987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 25-26
Record ID
BIM-29987