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Abatement by naringenin of doxorubicin-induced cardiac toxicity in rats
Joint Authors
Hafiz, Hafiz F.
Arafah, Husam M.
Abd Al-Ilah, Muhammad F.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 17, Issue 4 (31 Dec. 2005), pp.291-300, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2005-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background : Doxorubicin is one of the most active cytotoxic agents in current use.
It has proven efficacy in various malignancies either alone or combined with other cytocidal agents.
The clinical usefulness of the anthracycline drug has been precluded by cardiac toxicity.
Many therapeutic interventions have been attempted to improve the therapeutic benefits of the drug.
Few, however, have been efficacious in this setting.
Purpose : We have addressed in the current study the possible protective effects of naringenin, a flavonoid known to have anti-oxidant properties, on doxorubicininduced cardiac toxicity in male Swiss albino rats.
Methods : Forty male Swiss albino rats were used in this study.
Naringenin (25 mg / kg body weight) was administered daily by gavage for 7 consecutive days before a cumulative single dose of doxorubicin (15 mg / kg body weight, ip).
Results : Doxorubicin induced marked biochemical alterations characteristic of cardiac toxicity including, elevated activities of serum total lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), enhanced lipid peroxidation measured as malondialdehyde (MDA).
The anthracycline drug has also reduced the cardiac enzymatic activities of superoxide dismutase (SOD), glutathione-Stransferase (GST) and catalase (CAT).
Besides, it reduced significantly the reduced glutathione (GSH) level, but it increased the total NO content in heart tissue.
Prior administration of naringenin ahead of doxorubicin challenge ameliorated all these biochemical markers.
Conclusions : Taken together, one could conclude that naringenin has a protective role in the abatement of doxorubicin-induced cardiac toxicity that resides, at least in part, on its anti-radical effects and regulatory role on NO production.
American Psychological Association (APA)
Arafah, Husam M.& Abd Al-Ilah, Muhammad F.& Hafiz, Hafiz F.. 2005. Abatement by naringenin of doxorubicin-induced cardiac toxicity in rats. Journal of the Egyptian National Cancer Institute،Vol. 17, no. 4, pp.291-300.
https://search.emarefa.net/detail/BIM-29988
Modern Language Association (MLA)
Arafah, Husam M.…[et al.]. Abatement by naringenin of doxorubicin-induced cardiac toxicity in rats. Journal of the Egyptian National Cancer Institute Vol. 17, no. 4 (Dec. 2005), pp.291-300.
https://search.emarefa.net/detail/BIM-29988
American Medical Association (AMA)
Arafah, Husam M.& Abd Al-Ilah, Muhammad F.& Hafiz, Hafiz F.. Abatement by naringenin of doxorubicin-induced cardiac toxicity in rats. Journal of the Egyptian National Cancer Institute. 2005. Vol. 17, no. 4, pp.291-300.
https://search.emarefa.net/detail/BIM-29988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 298-300
Record ID
BIM-29988