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Immunodiagnosis of celiac disease among children with chronic diarrhea in Gaza Strip
Other Title(s)
التشخيص المناعي لمرض حساسية القمح بين الأطفال اللذين يعانون من الإسهال المتكرر في قطاع غزة
Dissertant
Thesis advisor
Shubayr, Muhammad E.
al-Khudari, Randah
University
Islamic University
Faculty
Faculty of Science
Department
Department of Biological Science
University Country
Palestine (Gaza Strip)
Degree
Master
Degree Date
2008
English Abstract
Celiac disease (CD) is a permanent intolerance to gluten that results in damage to the mucosa of the small intestine.
This damage consists of mucosal inflammation and loss of absorptive surface area and is manifested by a broad spectrum of symptoms and nutritional deficiencies.
The immune mediated damage to small bowel mucosa triggered by an immune response to the glia din fraction of gluten, a component of wheat, barley and oats.
CD can present at any age after the introduction of gluten into the diet.
During Infant and childhood CD can present with failure to thrive, vomiting, diarrhea, constipation, rickets, occipital seizures, and short stature.
In adults, CD may present with iron-deficiency anemia, diarrhea, infertility, nausea, vomiting, abdominal pain, weight loss, and pathologic fractures.
CD is associated with specific MHC class II alleles that map to the HLA-DQ locus, The HLA-DQ2, DQ8 alleles associated with increased susceptibility to CD.
Since there are no previous studies performed to evaluate the CD in our area, therefore this study was performed to determine the occurrence of CD among children suffering from chronic diarrhea in Gaza City, to investigate the role of ASMA in false negative EMAs results, to propose TTG as an alternative solution for masking problem and To highlight the CD in Gaza Strip for the first time.
The results of this study by using EMAs test showed an occurrence of CD (3.25 %).
But when they were analyzed by using (TTG IgG, IgA) the occurrence was (12.2 %).
Our results also showed that the occurrence of ASMA was (28.5 %), which may mask the EMAs antibodies and hence giving false negative results of EMAs, the four positive subjects for EMAs showed positive results when they were tested for (TTG IgG, IgA), these results mean that the two tests have the same sensitivity, and finally our finding showed that the total IgA deficiency represent (33.3 %) from all (TTG IgG, IgA) positive subjects, these results showed false negative results for (TTG IgA), so the class IgG of EMAs and TTG must be done to CD patients with total IgA deficiency.
It is recommended to follow the protocol in figure 6.1 for laboratory diagnosis of CD, to introduce the genetic analysis of CD to identify persons with increased risk of having the disease, and to adopt HPE as a golden standard test for clinical assessment of the patients with CD and to confirm the disease diagnosis.
Main Subjects
Topics
No. of Pages
77
Table of Contents
Abstract.
Table of contents.
Chapter one : Introduction.
Chapter two : Literature review.
Chapter three : Materials and methods.
Chapter four : Results.
Chapter five : Discussion.
Chapter six : Conclusion and recommendations.
References.
American Psychological Association (APA)
Rubi, Ahmad Mahmud. (2008). Immunodiagnosis of celiac disease among children with chronic diarrhea in Gaza Strip. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-303441
Modern Language Association (MLA)
Rubi, Ahmad Mahmud. Immunodiagnosis of celiac disease among children with chronic diarrhea in Gaza Strip. (Master's theses Theses and Dissertations Master). Islamic University. (2008).
https://search.emarefa.net/detail/BIM-303441
American Medical Association (AMA)
Rubi, Ahmad Mahmud. (2008). Immunodiagnosis of celiac disease among children with chronic diarrhea in Gaza Strip. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-303441
Language
English
Data Type
Arab Theses
Record ID
BIM-303441