Blood levels of protein C among intensive care unit patients in Gaza, Palestine
Other Title(s)
مستوى البروتين سي لدى مرضى وحدة العناية المركزة في قطاع غزة
Dissertant
Thesis advisor
Shubayr, Muhammad E.
Nabulusyah, Fawzi A.
University
Islamic University
Faculty
Faculty of Science
Department
Department of Biological Science
University Country
Palestine (Gaza Strip)
Degree
Master
Degree Date
2009
English Abstract
Background: Intensive care unit (ICU) is one of the largest, most expensive, and complex components of health care.
However, assessment of protein C (PC) and C- reactive protein (CRP) concentrations in ICU patients may help in identifying high risk groups and potential therapeutic targets.
Objective : to estimate the PC levels and CRP among ICU patients and their relations to ICU outcome.
Methods : this observational cross sectional study, in Al-Shifa hospital ICU, included 85 patients, and 85 healthy controls.
Plasma PC concentrations, and CRP levels were measured.
Kidney and liver dysfunctions were assessed biochemically ; in addition, coagulation tests were performed.
Results : PC levels were below the lower limit of normal in 65.9 % of patients (n = 56) at admission, irrespective of the presence primary diagnosis and sex.
PC levels were lower in non survivors (n = 17 ; 20 %) than in survivors.
There was significant correlation between PC levels and ICU outcome (P = 0.001).
Patients with high CRP levels upon ICU admission had higher mortality rates than patients with normal levels.
There was no significant correlation between CRP levels and ICU outcome (P = 0.856).
Conclusion : PC concentrations are generally low in ICU patients.
PC levels were also associated with organ dysfunction / failure and were independently associated with a higher risk of ICU mortality.
CRP levels are considered as a good early marker of morbidity and mortality in these patients.
In addition, CRP concentrations may be a valuable addition to predict the risk of death.
Main Subjects
Topics
No. of Pages
89
Table of Contents
Abstract.
Table of contents.
Chapter one : Introduction.
Chapter two : Literature review.
Chapter three : Materials and methods.
Chapter four : Results.
Chapter five : Discussion.
Chapter six : Conclusion and recommendations.
References.
American Psychological Association (APA)
Sarsour, Ohood R.. (2009). Blood levels of protein C among intensive care unit patients in Gaza, Palestine. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-303464
Modern Language Association (MLA)
Sarsour, Ohood R.. Blood levels of protein C among intensive care unit patients in Gaza, Palestine. (Master's theses Theses and Dissertations Master). Islamic University. (2009).
https://search.emarefa.net/detail/BIM-303464
American Medical Association (AMA)
Sarsour, Ohood R.. (2009). Blood levels of protein C among intensive care unit patients in Gaza, Palestine. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-303464
Language
English
Data Type
Arab Theses
Record ID
BIM-303464
