Anti thyroid antibodies among Palestinian women suffering from recurrent abortion in Gaza Strip

Other Title(s)

الأجسام المضادة للغدة الدرقية لدى المرأة الفلسطينية التي تعاني من الإجهاض المتكرر في قطاع غزة

Dissertant

al-Derawi, Sami S.

Thesis advisor

Yasin, Majid M.
Shubayr, Muhammad E.

University

Islamic University

Faculty

Faculty of Science

Department

Department of Biological Science

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2009

English Abstract

Recurrent pregnancy loss (RPL) is one of the most frustrating and difficult areas in reproductive medicine because the etiology is often unknown.

Autoimmunity has been directly associated in the etiology of several reproductive conditions including unexplained infertility and recurrent pregnancy loss.

This study focused on anti-thyroid autoantibodies and thyroid hormones as immunological and hormonal causative factors for RPL.

Because the human fetal thyroid does not secrete thyroid hormones until approximately 16 weeks of gestation, the fetus is dependent until that time on a supply from the maternal circulation.

The presence of thyroid autoantibodies among pregnant women may create very low thyroid hormones level which may be associated with an increased risk of miscarriages.

Aim : to investigate the relationship between anti-thyroid autoantibodies (TG-abs and TPO-abs) and recurrent pregnancy loss among women in Gaza strip, and to characterize thyroid hormones level in these spontaneous recurrent aborted women.

Methods: The study was case control study where two hundred women 18-30 years old who reside in Gaza strip were examined : 100 healthy non pregnant women with history of RPL during the first trimester as cases, and 100 healthy multigravida without any pervious abortion as a control group.

For all women in the two groups serum concentration for anti TG-abs, TPO-abs, thyroid stimulating hormone (TSH) and free thyroxine hormone (FT4) were measured using ELISA and MEIA.

Results : there was a statistically significant relation between recurrent pregnancy loss and anti TPO autoantibodies (X2 = 10.039, P = 0.002), where the majority of positive results were in cases as follow : 23.0 % of cases were positive for TPO antibodies compared to 7.0 % of control group.

Also there was a statistically significant relation between recurrent pregnancy loss and anti TG autoantibodies (X2 = 11.317, P = 0.001), where the majority of positive results were in cases as follow: 21% of cases were positive for TG antibodies compared to 5% of control group.

The results showed statistically significant relationship between anti-TPO Abs and anti-TG Abs with TSH level (X2 = 9.968, P = 0.002, and X2 = 5.977, P = 0.034, respectively).

Free T4 levels were normal in the two groups.

On other hand, there was no statistically significant relationship between thyroid antibodies and Toxoplasma, Cardiolipin and CMV antibodies among women in Gaza Strip.

Conclusion : recurrent pregnancy loss has a statistically significant relation with ant thyroid autoantibodies (TG-abs and TPO-abs), where 32 % of cases were positive for one or both (anti TPO antibodies and / or anti TG antibodies), while the positivity in control where 9.0 %.

Main Subjects

Biology

Topics

• Abortion
• Palestine
• Gaza Strip

No. of Pages

86

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-303476