Staphylococcus aureus nasal carriage, capsular polysaccharides serotypes and host immune response in end stage renal disease patients
Other Title(s)
دراسة العلاقة بين حمل مرضى غسيل الكلى لبكتيريا المكورات العنقودية الذهبية في الأنف و رد الفعل المناعي و النمط المصلي لهذا البكتيريا
Dissertant
Thesis advisor
Comitee Members
Hammudah, Wail
Farraj, Muhammad A.
University
Birzeit University
Faculty
Faculty of Science
Department
Department Nutrition and Dietetics
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2006
English Abstract
Staphylococcus aureus nasal carriage among patients on hemodialysis is considered a risk factor for endogenous S.
aureus vascular access infection.
During the period from May 2004 to January 2005, 99 end stage renal disease patients at Ramallah hospital, Augusta Victoria hospital, and Alia hospital were screened for nasal carriage of S.
aureus and 41 (41.4 %) were colonized by S.
aureus .
For the follow-up of the nasal carriage pattern, periodic nasal swabs were obtained and three S.
aureus nasal carriage pattern have been distinguished: persistent (17.17 %), intermittent (24.24 %), and non-carrier (58.6 %).
Most of the S.
aureus clinical isolates possessed capsular polysaccharides of multiple serological types, (48.15 %) possessed a polysaccharide type 5 capsule, (33.33 %) possessed a polysaccharide type 8 capsule, and the remaining (18.52 %) had capsular polysaccharide that were not typed by type 5 or type 8 antibodies. MRSA isolates were more likely to have different capsular polysaccharides types : CP5, CP8, and non 5 nor 8 capsular polysaccharides. The antibiotic susceptibility testing revealed that the S.
aureus strains fitted in 14 antibiogram types, with the type showing resistance only to Penicillin and Ampicillin prevalent in 48 out of 81 isolates ( 59.25 %). For better understanding of the immune response in ESRD patients to nasal S.
aureus, we used enzyme-immune linked assay to measure the concentration of anti-CP5 and anti-CP8 antibody.
The heterogeneity of the antibody level among ESRD patients in both carrier and non-carrier emphasized that there is no correlation between nasal carriage of S.
aureus and human immune response, and that high antibody concentration is not positively related to S.
aureus nasal carriage in ESRD patients.
Main Subjects
Topics
No. of Pages
49
Table of Contents
Table of contents.
Abstract.
Chapter one : Introduction.
Chapter two : Materials and methods.
Chapter three : Results.
Chapter four : Discussion.
References.
American Psychological Association (APA)
Zaydan, Fida Muhammad Salamah. (2006). Staphylococcus aureus nasal carriage, capsular polysaccharides serotypes and host immune response in end stage renal disease patients. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-303713
Modern Language Association (MLA)
Zaydan, Fida Muhammad Salamah. Staphylococcus aureus nasal carriage, capsular polysaccharides serotypes and host immune response in end stage renal disease patients. (Master's theses Theses and Dissertations Master). Birzeit University. (2006).
https://search.emarefa.net/detail/BIM-303713
American Medical Association (AMA)
Zaydan, Fida Muhammad Salamah. (2006). Staphylococcus aureus nasal carriage, capsular polysaccharides serotypes and host immune response in end stage renal disease patients. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-303713
Language
English
Data Type
Arab Theses
Record ID
BIM-303713
