Role of aqueous extract of apium graveolens seeds against the haematotoxicity induced by carbon tetrachloride in female rats

Abstract EN

The present study investigated the role of the aqueous extract of Opium grave lens seeds against the hepatotoxicity induced by carbon tetrachloride (CCl4) in female rats.

The females were divided into three groups each group contain six animals as the following : the first group was the control group, the second group treated intraperitoneal with 1 ml / kg of B.W.

of CCl4 for two weeks and the third group treated intraperitoneal with 1 ml/ kg of B.W.

of CCl4 + oral administration of 200 mg / kg of B.W.

of aqueous extract of Apia grave lens seeds for two weeks.

The result indicated that the CCl4 caused a significant reduction (p < 0.01) in the count of the erythrocyte (R.B.C), hemoglobin (Hob.) level, and total leukocyte (W.B.C.) count and non-significant decreased in the level of mean cell volume (MCV.) and Monocyte (MON.) percentage compared with the control group, also treated with the CCl4 caused non-significant increase in mean corpuscular hemoglobin concentration (MCHC.) level and Lymphocyte (LYM.) percentage compared with the female rats of control group .

Administered of aqueous extract of Opium grave lens seeds at 200 mg / kg of B.W.

for two weeks showed a significant increased (p < 0.01) in the count of erythrocyte (R.B.C.), hemoglobin (Hob.) level, and total leukocyte (W.B.C.) count, and non-significant increase in the mean cell volume (MCV.) level and percentage of Monocyte (MON.), also treated with aqueous extract of Opium grave lens seeds indicated non-significant decreased in mean corpuscular hemoglobin concentration (MCHC.) level and Lymphocyte (LYM.) percentage compared with the CCl4 treated group.

The study indicated the important effect of aqueous extract of Opium grave lens seeds in recovery of these hematological parameters above toward normal value compared with CCl4 treated group and compared with control group.