In vivo efficacy of nigella sativa aqueous seed extract against metacestode of echinococcus granulosus

Abstract EN

Hydatidosis is an endemic disease of human and animals which is difficult to treat.

Experimental studies indicated that Nigella sativa seeds had efficiency against various parasitic infections.

This study aimed to evaluate the in vivo efficiency of Nigella sativa aqueous seeds extract against Hydatidosis.

A total of 40 white albino mice were divided into 4 equal groups.

Each mouse in the first, second, and third groups were injected intraperitoneal (IP) with 2000 protoscolices, whereas mice in the fourth group were left as non-infected control.

Four months post infection, mice in the second and third group treated with 12 and 25mg of Nigella sativa aqueous seeds extract respectively in every other day for one week.

Mice in the first group were untreated and considered as infected control group.

Morphological and histopathologically changes in cysts and infected organs were studied.

Enzyme activities of adenosine deaminase (ADA) and alkaline phosphatase (ALP) were recorded in each mouse.

Mice from treated groups with either concentration had lower number and diameter of cysts and higher cost reduction percentage than infected control group.

Histological sections of the liver from mice treated with either concentration showed degeneration and necrosis of hydrated cysts.

An elevation of ADA and dropping in ALP activities was recorded in treated mice especially with 25 mg.