Effectiveness of glucosamine treatment on the modulation of some immunological parameters in patients with knee osteoarthritis

Abstract EN

The aim of this study was to determine the effect of oral glucosamine treatment that had prescribed to knee OA patients on the serum IFN-γ and IL-4.This study was included 40 patients had knee osteoarthritis on regular oral glucosamine.20 patients had osteoarthritis on acetaminophen only without glucosamine treatment (1stcontrol) and 20 healthy control peoples (2ndcontrol), their age ranged 40-67 and of both sex .Blood samples were taken from all groups and serum values of IFN-γ and IL-4 were measured by ELIZA technique.

Statistical analysis was done using the SPSS computing program at (p < 0.05) the level of significant.

The result showed that the concentration of IFN-γ and IL-4 in OA patients on glucosamine were significantly lower (p < 0.05) than that of both OA patients without glucosamine treatment and healthy group.

However, it was significantly higher (p < 0.05) in OA without glucosamine treatment as compared with healthy group.

The conclusion was glucosamine treatment can reduced the pro-inflammatory cytokines IFN-γ, IL-4 level in OA patients even below that of healthy control group.