Nephro-protective effect of punica granatum in gentamicin-induced nephrotoxicity in rats

Abstract EN

The aqueous extract of Punic a granum (AEPF) was investigated for its protective effects on gentamicin-induced renal toxicity in rats.

Nephrotoxicity was induced by intraperitoneal injection of gentamicin (100 mg / kg) for 8 days.

The effect of AEPF (100mg / kg) given orally either with gentamicin or after 8 days of gentamicin administration was assessed by biochemical and histopathologically changes of kidneys.

AEPF protected the rats from alteration in serum levels of urea, creatinine, uric acid, sodium, potassium and chloride better when co-administered with gentamicin than when given after induced gentamicin nephrotoxicity and also through reversing the mild tubular necrosis than severe tubular necrosis.