A theoretical study of substituted 2-pyridone2-hydroxypyridine tautomerism
Other Title(s)
دراسة نظرية لنظام 2-بيريدون و 2-هيدروكسي بيريدين المعوض
Dissertant
Thesis advisor
Comitee Members
al-Qudah, Muhammad Mustafa
al-Ashram, Muhammad Hasan
Qasir, Arab Khalil
University
Mutah University
Faculty
Faculty of Science
Department
Department of Chemistry
University Country
Jordan
Degree
Master
Degree Date
2007
English Abstract
All of the possible substitution positions on 2-Pyridone and hydroxypyridine were studied by the use of OH, CH3, CF3, F, NH2, NO2, and CHO substituents, and it is found that position 4 gives the most stable substituted compound.
Also, the effect of substituents (OH, CH3, CF3, F, NH2, NO2, and CHO) on the relative stability of 2-pyridone and 2-hydroxypyridine have been studied.
It is found that 2-pyridone is more stable than 2-hydroxypyridine by 3.117 kcal / mol, and the free energy ΔG was found to be 1.920 kcal / mol, which suggests that the tautomerization is shifted towards the keto form.
The MNDO program and MINDO-Forces was used to estimate optimized geometries, heat of formation, entropies, electron density and dipole moments for all of the substituted and substituted keto and enol compounds.
It is found that the bond lengths, bond angles and dipole moments are affected by the substituents especially at the position where the substituents are attached (position 4).
Also, the stabilizing effect of the substituents on the 2-pyridone and 2-hydroxypyridine were determined by Gibbs free energy (ΔG) and the isoseismic reactions.
All of the substituents studied were found not to effect the position of equilibrium.
The substituents OH, F, NH2 and CH3 were found to be electron releasing groups, where, NO2, CF3 and CHO were electron withdrawing groups.
Main Subjects
Topics
No. of Pages
64
Table of Contents
Table of contents.
Abstract.
Chapter one : Introduction.
Chapter two : Theoretical calculation.
Chapter three : Results and discussion.
References.
American Psychological Association (APA)
al-Sabayilah, Ahmad Ali Salim. (2007). A theoretical study of substituted 2-pyridone2-hydroxypyridine tautomerism. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-304605
Modern Language Association (MLA)
al-Sabayilah, Ahmad Ali Salim. A theoretical study of substituted 2-pyridone2-hydroxypyridine tautomerism. (Master's theses Theses and Dissertations Master). Mutah University. (2007).
https://search.emarefa.net/detail/BIM-304605
American Medical Association (AMA)
al-Sabayilah, Ahmad Ali Salim. (2007). A theoretical study of substituted 2-pyridone2-hydroxypyridine tautomerism. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-304605
Language
English
Data Type
Arab Theses
Record ID
BIM-304605