The effect of combined pills in abnormal uterine bleeding due to Norplant

Abstract EN

Objective : Comparison of two kinds of combined oral contraceptive pills (low and high dose)in control of abnormal uterine bleeding due to norplant.

Study Design : Norplant users complaining of abnormal uterine bleeding visited in health care services of Hamadan University, took part in a triple blind randomized clinical trial.

Regarding inclusion criteria, 100 women in three random groups took LDOCP (N = 33), HDOCP (N = 33) and placebo similarly.

Patients were monthly followed up with regard to abnormal bleeding until four months.

Drugs were decoded after data gathering.

Data analysis was done using SPSS software with one-way and two-way variance analysis test at the significance level of 0.05.

Result : Age, education level, number of children, length of norplant usage and bleeding days per month in the month before the study were not significantly different in three groups.

Mean bleeding days in the first month in the placebo, LDOCP and HDOCP groups were 15.7, 9.4 and 8.2 days respectively (p = 0.001).

Mean bleeding days in the second, third and fourth months of the study were not significantly different in the three groups.

Two variable variance analyses revealed time as a meaningful factor in mean bleeding days.

However, treatment modality and interaction of time and treatment were not meaningful.

Conclusion : Time was the most effective factor in bleeding of norplant users.

Contraceptive pills speed up bleeding reduction in the period of its prescription.