The effect of tannic acid on lipid per oxidation and lipid profile in ischemic heart disease patients

Dissertant

Mahmud, Abd al-Rahman R.

University

University of Technology

Faculty

-

Department

Applied Sciences Department

University Country

Iraq

Degree

Master

Degree Date

2004

English Abstract

The term ischemic heart disease(IHD) defines a disease spectrum of diverse etiology, with the common factor being an imbalance between myocardial oxygen supply and demand-Clinical expression of ischemic heart disease (I H D) falIs into the following groups : stable chronic angina, acute syndrome encompassing unstable angina, acute myocardial In frarction(AMI),and sudden ischemic death.

The production of free radicals and lipid peroxidation during the course of acute attack of ischemic heart disease may be a key feature, and hence important, of disease development.

In this study an attempted is made to shed a light on the possible relationships between lipid peroxidation marker, serum malondialdehyde (MDA), and the traditional biomarkers used for the diagnosis and evaluation of IHD scrum level of the lipid profile, total cholesterol, triglycerides, HDLc, LDLc and VLDLc.

Serum levels of the trace elements : zinc and calcium, zinc was evaluated and also correlated with the lipid peroxidation parameter, serum MDA and LDL.

Serum level of Vitamin E (a-TOH) as antioxidant, was correlated with MDA.

The results of the study indicate and confirm the role of lipid peroxidation, measured as MDA in serum in IHD patients which was found to be correlated very well with certain biomarksr.

Moreover, MDA was negatively correlated with (vit E) and zinc in serum of patients.

At last senim level of MDA was decreased to the level of healthy subjects after the addition of(0.01M) of tannic acid to scrum of patients with lHD.

Main Subjects

Medicine

Topics

• Oxidation
• Lipids
• Coronary heart diseases
• Diagnosis

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-306079