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Trypanocidal efficacy of diminazene in diabetic rats
Other Title(s)
تأثير الدايمينازين المميت للتريبانوسوما في الجرذان التي تعاني من السكري
Joint Authors
Chigozie, U. S.
Maduka, A. B.
Ifeanyi, J. G.
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 26, Issue 1 (30 Jun. 2012), pp.33-38, 6 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2012-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract AR
أجريت هذه الدراسة لمعرفة تأثير السكري على تأثير المميت للديمينازين على التريبانوسوما في الجرذان تم أحداث السكري بالألوكسان في الجرذان التي خمجت بالتريبانوسوما T.brucei andT.congolense و عولجت بالدايمينازين و لوحظ انخفاض تأثير الديمينازين ضد التريبانوسوما في الجرذان التي تعاني من داء السكري.
Abstract EN
The experiment was conducted to investigate the impact of hyperglycaemia on the trypanocidal efficacy of diminazene aceturate.
Groups of alloxan-induced diabetic rats infected with T.
brucei and T.
congolense were treated with diminazene aceturate, and trypanocidal effects compared with normal non-diabetic controls.
Results showed that the prepatent period was shorter in the diabetic (11.25 ± 1.65 days) than non-diabetic-T.
congolense (15.0 ± 1.73 days), and also variations in responses to the trypanocidal therapy between the diabetic and non-diabetic groups were detected.
Parasite clearance time did not differ significantly between the diabetic and non-diabetic (43.2 ± 8.89 versus 52.8 ± 8.89 hours in T.
brucei and 33.6 ± 5.9 versus 36.0 ± 6.93 hours in T.
congolense, respectively).
The relapse intervals were shorter in the diabetic than non-diabetic (16 days versus 23 days in T.
brucei, and 7 days versus 14 days in T.
congolense, respectively).
Proportion of relapses was greater in the diabetic- (100 %) than non-diabetic-T.
congolense (66.7 %).
We also find parasite species-related differences in susceptibility to the trypanocide, with a higher apparent cure rate in the T.
brucei than T.
congolense group.
We conclude from the results of this study that the chemotherapeutic effectiveness of diminazene aceturate may be diminished in patients with diabetes mellitus.
Further study is needed to validate this hypothesis.
American Psychological Association (APA)
Chigozie, U. S.& Maduka, A. B.& Ifeanyi, J. G.. 2012. Trypanocidal efficacy of diminazene in diabetic rats. Iraqi Journal of Veterinary Sciences،Vol. 26, no. 1, pp.33-38.
https://search.emarefa.net/detail/BIM-307247
Modern Language Association (MLA)
Chigozie, U. S.…[et al.]. Trypanocidal efficacy of diminazene in diabetic rats. Iraqi Journal of Veterinary Sciences Vol. 26, no. 1 (2012), pp.33-38.
https://search.emarefa.net/detail/BIM-307247
American Medical Association (AMA)
Chigozie, U. S.& Maduka, A. B.& Ifeanyi, J. G.. Trypanocidal efficacy of diminazene in diabetic rats. Iraqi Journal of Veterinary Sciences. 2012. Vol. 26, no. 1, pp.33-38.
https://search.emarefa.net/detail/BIM-307247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 37-38
Record ID
BIM-307247