The role T-helper-17 in toxoplasmosis among women with abortion

Abstract EN

The present study was carried out to evaluate the role of T-helper-17 through measuring serum level of IL-17 in infection with Toxoplasma gondii among women with abortion.

The present study was carried out on (35) women patients, all of them having abortion and proved by confirmatory tests that they have an active form of toxoplasma infection.

It also included twenty apparently healthy women as a control group.

The patients were between 15 to 50 years of age, they were attending AL-Zahraa Maternity and Child Teaching Hospital, AL-Hakeem Hospital and some private clinics, in Najaf governorate during the period between May 2010 to May 2011.

The Cytokines that were measured by ELISA technique were Interleukin-17(IL17), Interleukin-10 (IL10) and Gamma Interferon (IFNγ).

The study showed a high significant increase in serum level of IL-17 in patients with IgM Seropositivity (266.589pg / ml) when compared with serum levels in control and post treated groups (54.875pg / ml, 54.182pg / ml) respectively, whereas there was no significant differences in serum levels between those with Seropositivity with both IgM and IgG and levels in post treated and control groups.

The role T-helper-17 in the immune response against toxoplasmosis was studied in the current infection, it was found that there was a concomitant increase of IL-17 with the increase of T-helper-1 cytokine.