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Post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for hodgkin's lymphoma
Other Title(s)
اضطراب التكاثرية اللمفاوية ما بعد زرع الخلايا المكونة للدم لسرطان هودجكين للعقد اللمفاوية
Joint Authors
al-Maghribi, Jawdat Ahmad
Sayyadi, Hassan Hashim
al-Baz, Nabilah Muhammad
Bayyumi, Muhammad Salah al-Din
Source
Journal of King Abdulaziz University : Medical Sciences
Issue
Vol. 18, Issue 4 (31 Dec. 2011), pp.109-117, 9 p.
Publisher
King Abdulaziz University Scientific Publishing Center
Publication Date
2011-12-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract AR
اضطراب التكاثرية اللمفاوية ما بعد زرع نخاع العظم الذاتي هو أحد المضاعفات النادرة جدا.
نقدم تقريرا لحالة طفل مصاب بليفوما هودجكين الكلاسيكية, تم علاجه بزراعة خلايا جذعيه ذاتية.
بعد مضى ثلاثة أشهر, ظهر ورم في العقد اللمفاوية في الرقبة, و تضخم في الطحال.
الفحص النسيجي أظهر وجود اضطراب تكاثرية لمفاوية ما بعد الزراعة لخلايا من النوعين المتشابه و المختلف, و أظهرت اعتصارا للخلايا من نوع ب.
التحليل الجزيئي و تحليل الصبغات المناعية أظهر وجود وحدة جينية.
كذلك الصبغات المناعية و الوميضية لفيروس الايبيشتاين بار كانت إيجابية.
عولج المريض بالستيرويدات لمدة أسبوعين تم إنقاصها التدريجي على مدى ثلاثة أشهر, و استجابة المريض بشكل جيد.
في آخر زيارة للمريض كان بصحة جيدة بعد مرور سنتين من التشخيص.
Abstract EN
Post-transplant lymph proliferative disorder is a very rare complication post autologous bone marrow transplant with few cases reported so far.
We report a case of a child with history of classic Hodgkin's lymphoma, nodular sclerosis type, who was treated with autologous stem cell transplantation.
Three months after the transplant, he developed bilateral cervical lymphadenopathy, splenomegaly, neutropenia and thrombocytopenia.
Excisional biopsy of a left cervical lymph node revealed a post-transplant lymph proliferative disorder.
The morphological pattern of this post-transplant lymph proliferative disorder was combined monomorphic and polymorphic, with plasmacytoid / plasmablastic differentiation expressing CD20 and CD79A.
Kappa and lambda light chain immunohistochemistry stains showed a clear evidence of lambda light chain restriction.
Immunohistochemistry stain and in situ hybridization for Latent membrane protein-1 were positive for Epstein-Barr virus.
Polymerase chain reaction study revealed monoclonal B-cell proliferation with immunoglobulin heavy chain gene rearrangement.
The patient was treated with prednisolone as 2 mg / kg / day over 2 weeks with tapering over the following 3 months.
The white cell count recovered with regression of splenomegaly and cervical lymphadenopathy.
On his last visit to the outpatient clinic, two years after the diagnosis of post-transplant lymph proliferative disorder, he was in good health with normal laboratory parameters.
American Psychological Association (APA)
al-Maghribi, Jawdat Ahmad& Sayyadi, Hassan Hashim& al-Baz, Nabilah Muhammad& Bayyumi, Muhammad Salah al-Din. 2011. Post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for hodgkin's lymphoma. Journal of King Abdulaziz University : Medical Sciences،Vol. 18, no. 4, pp.109-117.
https://search.emarefa.net/detail/BIM-308553
Modern Language Association (MLA)
al-Maghribi, Jawdat Ahmad…[et al.]. Post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for hodgkin's lymphoma. Journal of King Abdulaziz University : Medical Sciences Vol. 18, no. 4 (2011), pp.109-117.
https://search.emarefa.net/detail/BIM-308553
American Medical Association (AMA)
al-Maghribi, Jawdat Ahmad& Sayyadi, Hassan Hashim& al-Baz, Nabilah Muhammad& Bayyumi, Muhammad Salah al-Din. Post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for hodgkin's lymphoma. Journal of King Abdulaziz University : Medical Sciences. 2011. Vol. 18, no. 4, pp.109-117.
https://search.emarefa.net/detail/BIM-308553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 114-116
Record ID
BIM-308553