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Role of central corneal thickness in circadian intraocular pressure fluctuations among patients with primary open angle glaucoma
Joint Authors
al-Budur, Muhannad Q.
Kooner, Karanjit S.
Source
Journal of the Royal Medical Services
Issue
Vol. 19, Issue 2 (30 Jun. 2012), pp.51-55, 5 p.
Publisher
The Royal Medical Services Jordan Armed Forces
Publication Date
2012-06-30
Country of Publication
Jordan
No. of Pages
5
Main Subjects
Topics
Abstract EN
-Objectives: To determine how central corneal thickness in patients with primary open-angle glaucoma correlates with intraocular pressure diurnal fluctuations.
This study also verifies the effect of positioning (supine or sitting) on intraocular pressure.
Methods: This study was conducted on a 38 subjects with mild to moderate primary open angle glaucoma were recruited and evaluated for 24 hours in a controlled environment, having their intraocular pressure measured.
During the hours of 7:00 AM to 9:00 PM, intraocular pressure was measured in the sitting and supine positions, while in the hours of 11:00 PM to 5:00 AM they were made in the supine position only.
Patients were maintained on their normal medication schedules.
Baseline information was gathered from clinical charts in addition to a detailed patient history.
Results: The mean circadian intraocular pressure fluctuation was 8.8 (3.2) mmHg (p<0.0001).
Night time intraocular pressures were on an average 2.3 (2.6) mmHg higher than day time pressures (p<0.0001).
Daytime supine pressures were significantly higher than sitting by 2.8 (1.1) mmHg, (p<0.0001), but daytime supine mean IOP 19.9 (4.0) mmHg was lower than night time supine intraocular pressure of 20.8(4.3), (p=0.04).
Intraocular pressure fluctuations were greater among patients with thinner central corneas.
Inverse relationship was observed between central corneal thickness and daytime supine intraocular pressure flux (Spearman rho= - 0.39, p=0.02) and between central corneal thickness and night time supine intraocular pressure flux (rho = - 0.37, p=0.02).
Conclusion: This study has shown that significant fluctuations in intraocular pressure still occur in clinically controlled patients with primary open-angle glaucoma.
And that those patients with thinner corneas show greater diurnal intraocular pressure fluctuations than patients with thicker corneas.
Furthermore, supine intraocular pressure measurement may provide a more clinically relevant picture in those patients, as compared to sitting pressures.
American Psychological Association (APA)
al-Budur, Muhannad Q.& Kooner, Karanjit S.. 2012. Role of central corneal thickness in circadian intraocular pressure fluctuations among patients with primary open angle glaucoma. Journal of the Royal Medical Services،Vol. 19, no. 2, pp.51-55.
https://search.emarefa.net/detail/BIM-308872
Modern Language Association (MLA)
al-Budur, Muhannad Q.& Kooner, Karanjit S.. Role of central corneal thickness in circadian intraocular pressure fluctuations among patients with primary open angle glaucoma. Journal of the Royal Medical Services Vol. 19, no. 2 (Jun. 2012), pp.51-55.
https://search.emarefa.net/detail/BIM-308872
American Medical Association (AMA)
al-Budur, Muhannad Q.& Kooner, Karanjit S.. Role of central corneal thickness in circadian intraocular pressure fluctuations among patients with primary open angle glaucoma. Journal of the Royal Medical Services. 2012. Vol. 19, no. 2, pp.51-55.
https://search.emarefa.net/detail/BIM-308872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 54-55
Record ID
BIM-308872