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Expression of adhesion molecule CD44V6 in salivary gland tumors
Other Title(s)
تعبير جزيئات التماسك السي دي 44 في أورام الغدد اللعابية
Joint Authors
Shalabi, Iman Muhammad Salah al-Din Muhammad
Fadil, Sabah Ahmad Muhammad
al-Nabi, Nuha al-dab Hasab
Sharqawi, Kamal Abd al-Al
Source
Issue
Vol. 32, Issue 1 (31 Jan. 2008), pp.49-62, 14 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2008-01-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Topics
Abstract AR
يعد تعيير المتغير السادس لسي دي 44 نمطا تركيبا ظاهريا للخلايا الطلائية و العضلية الظهارية في الغدد اللعابية و التي تزيد درجته في اورام الغدد اللعابية الحميدة و تنقض في الاورام الخبيثة.
و يزداد نقص تعبير المتغير السادس لسي دي 44 بزيادة درجة الورم و بحدوث انتشار للورم في الغدد الليمفاوية.
Abstract EN
Salivary gland tumors are a morphologically and clinically diverse group of neoplasms which may present significant diagnostic and management challenges.
Cell adhesion molecules (CAMsj are glyco-proteins that are present on the external surface of the cell membrane.
CD44 is a cell adhesion molecule belonging to systemic IgCAMs family, and is remarkable for its ability to generate alternatively spliced forms, many of which differ in their activities.
This remarkable flexibility has led to speculation that CD44, via its changing nature, plays a role in some of the methods that tumor cells use to progress successfully through growth and metastasis.
Aim of the work: to investigate the expression of CD44v6 in different types of salivary glands tumors and to correlate the results with some established prognostic factors.
Materials and methods: Sixty cases were studied.
21 were pleomorphic adenomas, 9 Warthins tumors, 6 monomorphic adenomas, 9 mucoepidermoid carcinomas, five adenoid cystic carcinomas, in addition to 10 normal controls.
Clinical data were obtained from the referring clinical departments.
The biopsy specimens were obtained by excision, true cut needle biopsy, or punch biopsy.
Cases were selected by reviewing the hematoxylin and eosin (H&E) stained slides.
Immunohistochemistry was done using the CD44v6 mouse monoclonal antibody raised against human species.
Results: CD44v6 was + ve in 46 / 60 (76.7%) of salivary gland tumors studied; 35 / 40 (87.5%) benign salivary glands tumors and 11 / 20 (55%) malignant salivary gland tumors and this difference was statistically significant (P < 0.01).
CD44v6 was +ve in 16 / 21 (76%) of pleomorphic adenoma, in 9 / 9 (100%) of War thin's tumors and in 6 / 6 of monomorphic adenoma. CD44v6 was + ve in 5 / 9 of mucoepidermoid carcinoma; 4 / 5 (80%) of low and intermediate grade mucoepidermoid carcinoma and.
in 1 / 4 (25%) of high grade malignant mucoepidermoid carcinoma.
The 4 studied high grade malignant mucoepidermoid carcinoma were lymph node metastasis +ve.
CD44V6 was + ve in 4 / 5 (80%) of adenoid cystic carcinoma. There was a statistically significant decrease in CD44v6 positivity (P < 0.03) in high grade malignant salivary gland tumors compared to low and intermediate grade tumors.
There was also a statistically significant decrease in CD44v6 positivity (P < 0.01) in malignant salivary gland tumors received with lymph node metastasis compared with those lymph node metastasis negative cases.
Conclusion: 1- Down regulation of CD44v6 plays an important role in malignant transformation of salivary gland tumors.
2- The degree of down-regulation is correlated with progression towards higher grades and also with lymph node metastasis.
American Psychological Association (APA)
Shalabi, Iman Muhammad Salah al-Din Muhammad& Fadil, Sabah Ahmad Muhammad& al-Nabi, Nuha al-dab Hasab& Sharqawi, Kamal Abd al-Al. 2008. Expression of adhesion molecule CD44V6 in salivary gland tumors. Assiut Medical Journal،Vol. 32, no. 1, pp.49-62.
https://search.emarefa.net/detail/BIM-30921
Modern Language Association (MLA)
Fadil, Sabah Ahmad Muhammad…[et al.]. Expression of adhesion molecule CD44V6 in salivary gland tumors. Assiut Medical Journal Vol. 32, no. 1 (Jan. 2008), pp.49-62.
https://search.emarefa.net/detail/BIM-30921
American Medical Association (AMA)
Shalabi, Iman Muhammad Salah al-Din Muhammad& Fadil, Sabah Ahmad Muhammad& al-Nabi, Nuha al-dab Hasab& Sharqawi, Kamal Abd al-Al. Expression of adhesion molecule CD44V6 in salivary gland tumors. Assiut Medical Journal. 2008. Vol. 32, no. 1, pp.49-62.
https://search.emarefa.net/detail/BIM-30921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 60-62
Record ID
BIM-30921