Effect of toxoplasmosis on the histological structure of the mast cells in the mice eye

Abstract EN

Objective : this study is concerned with the effect of toxoplasmosis on the histology of the mast cells in the mice eye.

Methods : the mice were inoculcated intraperitoneal with placental fluid containing Toxoplasma Gondii parasite to induce the infection.

After 10-15 days of inoculation, the eyes of the mice were examined histologically by the light microscope.

Isolation of Toxoplasma Gondii parasite from pregnant women suffered from acute Toxoplasmosis and their infection was proved by ELISA test showing the presence of IgM antibodies against the parasite in their blood.

Placental fluid was taken from those women after abortion and inoculated intraperitoneal in the mice.

Results : many histological changes observed in the eyes of the injected mice.

Histologically, the eyes of the mice showed the presence of the parasite tachyzoites and bradyzoites invade the eyes together with intense inflammatory cellular infiltration, vasodilatation involving iris and retina; congestion and hemorrhage in the anterior region of the eye with accumulation of mast cells.

All these changes indicated that the infection with Toxoplasma Gondii parasite could affect all the body organs including the eye.

Conclusions : toxoplasma Gondii parasites invade all the layers of the eye leading to destruction of the eye, in addition to activation of the mast cells as an important cells in the immune system and their relation to the hypersensitivity reaction in the eyes.