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The effects of calcitriol on albuminuria in patients with type-2 diabetes mellitus
Joint Authors
Hami, Maryam
Hatefi, Asieh
Bonakdaran, Shokoufeh
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 23, Issue 6 (31 Dec. 2012), pp.1215-1220, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2012-12-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
- Diseases
- Patients
- Diabetes
- Non-insulin-dependent diabetes
- Steroid hormones
- Side effects
- Analysis
- Diabetic Nephropathy
- Kidneys
- Microalbuminuria
- Calcitriol
Abstract EN
The renin–angiotensin system has a major role in the development of diabetic nephropathy (DN).
It is reported that vitamin D analogues are able to suppress renin excretion.
Thus, this study was conducted to determine whether there is any correlation between albuminuria as a marker of DN with vitamin D levels in diabetic patients.
Also, an assessment was made on the effects of vitamin D therapy on albuminuria in this group of patients.
We conducted this cross-sectional study on 119 outpatients with type-2 diabetes.
The serum levels of 25-hydroxy vitamin D [25 (OH) D] and the albumin to creatinine ratio were assessed in all the study patients.
Patients with vitamin D deficiency / insufficiency received calcitriol therapy for eight weeks, following which the laboratory tests were repeated.
The mean age of the study patients was 55.3 11.2 ± years, 43 (36.13 %) had vitamin D insufficiency [25 (OH) D < 25 ng / mL] and 31 (26.1 %) had vitamin D deficiency [25 (OH) D < 15 ng / mL].
We found a significant correlation between 25 (OH) D levels and presence of microalbuminuria (P = 0.04) in patients with vitamin D deficiency.
Therapy with calcitriol had a beneficial effect on the albumin excretion rate, although this change was not significant (P = 0.22).
However, the effects of calcitriol on reduction of diastolic blood pressure (P = 0.004), glycosylated hemoglobin (P = 0.014) and levels of total cholesterol (P = 0.019), low-density lipoprotein (0.04) and high-density lipoprotein (P = 0.001) was significant.
Our study suggests that vitamin D deficiency has a negative effect on albuminuria in diabetic patients, and its replacement may be associated with a beneficial effect on the risk factors of DN, such as hyperlipidemia and hypertension.
American Psychological Association (APA)
Bonakdaran, Shokoufeh& Hami, Maryam& Hatefi, Asieh. 2012. The effects of calcitriol on albuminuria in patients with type-2 diabetes mellitus. Saudi Journal of Kidney Diseases and Transplantation،Vol. 23, no. 6, pp.1215-1220.
https://search.emarefa.net/detail/BIM-310887
Modern Language Association (MLA)
Bonakdaran, Shokoufeh…[et al.]. The effects of calcitriol on albuminuria in patients with type-2 diabetes mellitus. Saudi Journal of Kidney Diseases and Transplantation Vol. 23, no. 6 (Dec. 2012), pp.1215-1220.
https://search.emarefa.net/detail/BIM-310887
American Medical Association (AMA)
Bonakdaran, Shokoufeh& Hami, Maryam& Hatefi, Asieh. The effects of calcitriol on albuminuria in patients with type-2 diabetes mellitus. Saudi Journal of Kidney Diseases and Transplantation. 2012. Vol. 23, no. 6, pp.1215-1220.
https://search.emarefa.net/detail/BIM-310887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1219-1220
Record ID
BIM-310887