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Efficacy of influenza vaccination in patients with cirrhosis and inactive carriers of hepatitis B virus infection
Joint Authors
Alavian, S. M.
Behnava, B.
Sayyad, B.
Najafi, F.
Azad, T. Mokhtari
Tabarestani, M. H. Ari
Shirvani, M.
Afshrian, M.
Vaziri, S.
Janbakhsh, A. R.
Mansuri, F.
Kaviani, Sh.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 10 (31 Oct. 2012)8 p.
Publisher
Publication Date
2012-10-31
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Influenza can causes morbidity and mortality that are greatly enhanced in patients with underlying chronic diseases such as Cirrhotic patients.
This study was performed to assess the immunogenicity of Influenza vaccination in patients with cirrhosis and inactive carriers of Hepatitis B virus infection. Methods : In this clinical study 93 enrolled subjects divided into 3 groups : Cirrhotic (N = 28), Inactive carriers of Hepatitis B (N = 31) and subjects (N = 34).
All the participants were vaccinated by Influenza vaccine (Influvac®).
Serum samples were taken before and 4 weeks after vaccination and the Humoral Immunogenicity was assessed by the Hemagglutination iInhibition (HI) test. Results : Four weeks after vaccination, seroconversion rates of vaccine strains ranged between 71.4 % and 100 % in Group 1, 70.6 % and 94.1 % in Group 2, and 58.1 % and 80.7 % in Group 3.
No significant differences were seen in the rates of Seroconversion and antibody Geometric Mean Titers (GMTs) against Influenza A (H1N1 and H3N2) vaccine components in the three groups (P > 0.05).The rates of Seroconversion and antibody GMTs against Influenza B vaccine component were significantly higher in Cirrhotic and inactive carriers of Hepatitis B than healthy subjects (P < 0.005).
No significant (P > 0.05) differences in the rates of Seroprotection were observed within the three groups.
Antibody GMTs against all three strains of Influenza vaccine increased significantly (P < 0.001) after vaccination in three groups. Conclusion : Influenza vaccination is effective in Cirrhotic patients and inactive carriers of Hepatitis B as well as healthy individuals.
It means that vaccination should be considered in such patients in order to reduce the morbidity and mortality of Influenza.
American Psychological Association (APA)
Sayyad, B.& Alavian, S. M.& Najafi, F.& Azad, T. Mokhtari& Tabarestani, M. H. Ari& Shirvani, M.…[et al.]. 2012. Efficacy of influenza vaccination in patients with cirrhosis and inactive carriers of hepatitis B virus infection. Iranian Red Crescent Medical Journal،Vol. 14, no. 10.
https://search.emarefa.net/detail/BIM-310993
Modern Language Association (MLA)
Sayyad, B.…[et al.]. Efficacy of influenza vaccination in patients with cirrhosis and inactive carriers of hepatitis B virus infection. Iranian Red Crescent Medical Journal Vol. 14, no. 10 (Oct. 2012).
https://search.emarefa.net/detail/BIM-310993
American Medical Association (AMA)
Sayyad, B.& Alavian, S. M.& Najafi, F.& Azad, T. Mokhtari& Tabarestani, M. H. Ari& Shirvani, M.…[et al.]. Efficacy of influenza vaccination in patients with cirrhosis and inactive carriers of hepatitis B virus infection. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 10.
https://search.emarefa.net/detail/BIM-310993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references.
Record ID
BIM-310993