Noise-induced outer hair cells' dysfunction and cochlear damage in rabbits
Joint Authors
Najarkola, S. A. Moussavi
Khavanin, A.
Mirzaei, R.
Salehnia, M.
Muhammadnejad, A.
Akbari, M.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 10 (31 Oct. 2012)10 p.
Publisher
Publication Date
2012-10-31
Country of Publication
United Arab Emirates
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background : Outer hair cells' (OHCs') dysfunctions as the extent of temporary and permanent threshold shifts (TTS and PTS) and cochlear damage were assessed in rabbits exposed to continuous noise. Methods : Twelve New Zealand white rabbits were studied in noise (N) (n = 6 ; exposed to continuous noise ; 95dB SPL, 500-8000 Hz for 8 h per day during 5 consecutive days) and control (C) (n = 6 ; not exposed to noise).
OHCs' functions were assessed by distortion product otoacoustic emission (DPOAE) level (Ldp) measurements in different periods and comparing TTS and PTS.
Animals were anaesthetized by CO2 ; cochleae were extracted, fixed in 10 % formaldehyde for 48 hours, decalcified by 10 % nitric acid for 24 hours, and dehydrated, embedded, sectioned 5 µm thickness and stained by Hematoxylin and Eosin for light microscopy. Results : The most and least Ldp or TTS or PTS were related to 5888.50 Hz and 588.00 Hz respectively in noise subjected rabbits (P<0.05).
TTS and PTS were decreased up to 17.79 dB and to 16.01 dB respectively.
TTS were more than PTS over all test frequencies, especially at 5888.50 Hz (P < 0.05).
Ldp or TTS or PTS were found to be equal across ears (P > 0.05).
Severely vacuolated OHCs, pyknotic IHCs, swollen SC, and slightly thickened BM were found. Conclusion : Continuous noise extensively led to OHCs' dysfunctions as decreased Ldp (both TTS and PTS) and highly damage to cochlea.
American Psychological Association (APA)
Najarkola, S. A. Moussavi& Khavanin, A.& Mirzaei, R.& Salehnia, M.& Muhammadnejad, A.& Akbari, M.. 2012. Noise-induced outer hair cells' dysfunction and cochlear damage in rabbits. Iranian Red Crescent Medical Journal،Vol. 14, no. 10.
https://search.emarefa.net/detail/BIM-311004
Modern Language Association (MLA)
Muhammadnejad, A.…[et al.]. Noise-induced outer hair cells' dysfunction and cochlear damage in rabbits. Iranian Red Crescent Medical Journal Vol. 14, no. 10 (Oct. 2012).
https://search.emarefa.net/detail/BIM-311004
American Medical Association (AMA)
Najarkola, S. A. Moussavi& Khavanin, A.& Mirzaei, R.& Salehnia, M.& Muhammadnejad, A.& Akbari, M.. Noise-induced outer hair cells' dysfunction and cochlear damage in rabbits. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 10.
https://search.emarefa.net/detail/BIM-311004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references.
Record ID
BIM-311004