Randomized control trial : comparison of triple therapy plus probiotic yogurt vs. standard triple therapy on helicobacter pylori eradication

Abstract EN

Background : Treatment of Helicobacter pylori (H.

pylori) as a major cause of gastric diseases is of utmost concern.

We aimed to assess efficacy of triple therapy (amoxicillin, clarithromycin and pantoprazole) plus probiotic yogurt (PY) on eradication of H.pylori. Methods : Total 102 H.

pylori positive patients were divided to 3 groups equally and randomly.

For treatment of each group Amoxicillin, clarithromycin and pantoprazole were used.

Group A had additional PY, Group B ordinary low fat yogurt and Group C just had triple therapy in their regimen as well.

These groups were compared regarding treatment success. Results : Total number of 88 patients finished the treatment course.

The most common experienced side effects were dysgeusia in groups A and B (25.8 % and 32.3 %, respectively), and dysgeusia with diarrhea and abdominal pain (30.8 %) in group C.

Eradication rate was, respectively, 61.3%, 64.5% and 71.3 % in group A, B and C of which difference was not statistically significant (P > 0.05).

However, the difference between 3 groups in regard to education level was statistically significant (P = 0.005). Conclusion : PY enriched triple therapy has decreased side effects of antibiotics consumption ; however, this has no impact on eradication of Hpylori.

PY and triple therapy can be used concomitantly to increase the patient tolerance.