Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients : a double-blind randomized controlled trial
Joint Authors
Ghanei, E.
Zeinali, J.
Borghei, H.
Homayouni, M.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 9 (30 Sep. 2012)8 p.
Publisher
Publication Date
2012-09-30
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Uremic pruritus is a common and bothersome complaint among end-stage renal disease which affect between 25 % and 60 % of this population .But there is no decisive cure for treatment of it.
In this study, the effects of omega-3 for treatment of pruritus were investigated in hemodialysis patients. Methods : A double-blind randomized study was carried out in the form of placebo-controlled crossover study in four dialysis centers in Tehran, Iran during 2008.
At first, 22 hemodialysis patients suffering from pruritus with previous drug resistance were selected.
Next, these patients were randomly allocated into two groups of omega-3-placebo (group A) and placebo-omega-3 (group B).
Patients in group A were treated with a 1-gram Fish oil capsule for 20 days, and subsequently, they were treated with placebo for 20 days after a 14-day wash-out period .But the reverse act was done in group B.
The pruritus assessment was made quantitatively through Detailed Pruritus Score. Results : Pruritus was decreased up to 65 % from score mean of 20.3 (95 % CI: 16.7-23.8) to 6.4 (95 % CI : 2.9-9.8) in omega-3 group and the decrease in the placebo group was 15 % from score mean of 17.0 (95 % CI : 12.4-21.6) to 14.4 (95 % CI : 10.5-18.2).So the level of statistical difference was significant (P = 0.0001). Discussion : Omega-3 fatty acids found to be more effective than placebo in decreasing of uremic pruritus.
So it seems that Omega-3 fatty acids could be used as an efficient drug for treatment of pruritus in uremic patients.
American Psychological Association (APA)
Ghanei, E.& Zeinali, J.& Borghei, H.& Homayouni, M.. 2012. Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients : a double-blind randomized controlled trial. Iranian Red Crescent Medical Journal،Vol. 14, no. 9.
https://search.emarefa.net/detail/BIM-311021
Modern Language Association (MLA)
Ghanei, E.…[et al.]. Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients : a double-blind randomized controlled trial. Iranian Red Crescent Medical Journal Vol. 14, no. 9 (Sep. 2012).
https://search.emarefa.net/detail/BIM-311021
American Medical Association (AMA)
Ghanei, E.& Zeinali, J.& Borghei, H.& Homayouni, M.. Efficacy of omega-3 fatty acids supplementation in treatment of uremic pruritus in hemodialysis patients : a double-blind randomized controlled trial. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 9.
https://search.emarefa.net/detail/BIM-311021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references.
Record ID
BIM-311021