Synthesis of some new chalcone and 4, 5-dihydro-1H-pyrazole derivatives as potential antimicrobial agents
Joint Authors
Abu al-Halawah, Rajab
Ibrahim, Muhammad M.
al-Rifai, Mahmud
al-Suhaili, Suhil
Masad, Muhannad
Tashtush, Hasan
Source
Issue
Vol. 7, Issue 2 (30 Jun. 2012), pp.115-123, 9 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2012-06-30
Country of Publication
Jordan
No. of Pages
9
Main Subjects
Topics
Abstract EN
Condensation of 3-acetyl-2, 5-dichlorothiophene with 1- or 2-naphthaldehyde led to the formation of the new chalcones (3a, b) in high yields.
The latter chalcones were used as a back bone for the synthesis of substituted 3-(2, 5-dichlorothiophen-3-yl)-4, 5-dihydro-5- (naphthalen-1 or 2- y naphthalen-1 or l)-1H-pyrazole (4a-h) in good yields.
All newly synthesized compounds were characterized by standard spectroscopic techniques.
The microbiological activity of these new compounds was investigated against bacteria and fungi.
The new compounds showed good to excellent activity against all microbial species used for screening.
American Psychological Association (APA)
Ibrahim, Muhammad M.& al-Rifai, Mahmud& Abu al-Halawah, Rajab& Tashtush, Hasan& al-Suhaili, Suhil& Masad, Muhannad. 2012. Synthesis of some new chalcone and 4, 5-dihydro-1H-pyrazole derivatives as potential antimicrobial agents. Jordan Journal of Chemistry،Vol. 7, no. 2, pp.115-123.
https://search.emarefa.net/detail/BIM-311138
Modern Language Association (MLA)
Ibrahim, Muhammad M.…[et al.]. Synthesis of some new chalcone and 4, 5-dihydro-1H-pyrazole derivatives as potential antimicrobial agents. Jordan Journal of Chemistry Vol. 7, no. 2 (Jun. 2012), pp.115-123.
https://search.emarefa.net/detail/BIM-311138
American Medical Association (AMA)
Ibrahim, Muhammad M.& al-Rifai, Mahmud& Abu al-Halawah, Rajab& Tashtush, Hasan& al-Suhaili, Suhil& Masad, Muhannad. Synthesis of some new chalcone and 4, 5-dihydro-1H-pyrazole derivatives as potential antimicrobial agents. Jordan Journal of Chemistry. 2012. Vol. 7, no. 2, pp.115-123.
https://search.emarefa.net/detail/BIM-311138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 123
Record ID
BIM-311138