Use of charge transfer complex formation reaction in spectrophotometric microdetermination of some drugs
Joint Authors
al-Sabha, Theiaa N.
al-Ghabsha, Thabit S.
al-Enizzi, Muhammad S.
Source
Issue
Vol. 7, Issue 1 (31 Mar. 2012), pp.87-102, 16 p.
Publisher
Yarmouk University Deanship of Research and Graduate Studies
Publication Date
2012-03-31
Country of Publication
Jordan
No. of Pages
16
Main Subjects
Topics
Abstract EN
A spectrophotometric method is proposed for the determination of isoniazid, mesalazine, salbutamol and thymol drugs in their pure forms and in pharmaceutical preparations, based on the charge-transfer (CT) complex formation reaction with o-chloranil as π-acceptor.
Linear calibration graphs were obtained in the concentration range 1-16 and 2-20 μg ml-1 for isoniazid at 360 and 520 nm respectively, 1.25-30 μg ml-1 at 571.5 nm for mesalazine, 1.25-50 μg ml-1 for salbutamol and 2.5-80 μg ml-1 at 410 nm for thymol at room temperature.
The molar absorptivity values are in the range 3460 and 14360 l.mol-1.cm-1 and the lower limit of detection limits are in the rang 0.1432-1.3164 μg ml-1 for all the studied drugs.
The stoichiometry of the drug-ochloranil complexes was found to be 1:1 except mesalazine which was found to be 1:2.
No interference was observed from common pharmaceutical excipients.
The procedure is characterized by its simplicity with accuracy and precision.
The proposed method was applied successfully for the determination of the drugs in their pharmaceutical formulations.
American Psychological Association (APA)
al-Enizzi, Muhammad S.& al-Sabha, Theiaa N.& al-Ghabsha, Thabit S.. 2012. Use of charge transfer complex formation reaction in spectrophotometric microdetermination of some drugs. Jordan Journal of Chemistry،Vol. 7, no. 1, pp.87-102.
https://search.emarefa.net/detail/BIM-311160
Modern Language Association (MLA)
al-Enizzi, Muhammad S.…[et al.]. Use of charge transfer complex formation reaction in spectrophotometric microdetermination of some drugs. Jordan Journal of Chemistry Vol. 7, no. 1 (Mar. 2012), pp.87-102.
https://search.emarefa.net/detail/BIM-311160
American Medical Association (AMA)
al-Enizzi, Muhammad S.& al-Sabha, Theiaa N.& al-Ghabsha, Thabit S.. Use of charge transfer complex formation reaction in spectrophotometric microdetermination of some drugs. Jordan Journal of Chemistry. 2012. Vol. 7, no. 1, pp.87-102.
https://search.emarefa.net/detail/BIM-311160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 101-102
Record ID
BIM-311160