Evaluation of antihyperglycemic and other complication effects of extracts of thespesia iampas dalz and gibs on streptozotocin induced diabetic rats

Abstract EN

The methanol and aqueous extracts of Thespesia lampas Dalz and Gibs were tested for anti-hyperglycemic, antihyperlipidaemic and spermatogenetic effects of streptozotocin (STZ) induced diabetic rats.

Diabetes was induced in adult male albino Wister rats by intra peritoneal (i.

p) injection of streptozotocin at a dose of 150 mg / kg.

Methanol and aqueous extracts of T.

lampas (METL and AETL) at doses of 300 and 600 mg / kg b.

wt were administered as a single dose per day to diabetes rats for the period of 15 days, respectively.

The blood glucose levels and serum lipid profiles like total cholesterol, triglycerides, phospholipids, low density, very low density and high density lipoprotein and serum enzymes like ALT, ASP, ALP were measured in the diabetic and non diabetic rats.

An oral glucose tolerance test (OGTT) was also performed, in which there was a significant improvement in glucose tolerance in rats treated with extracts.

A comparison was made between the extracts and standard anti-diabetic drug glibenclamide.

The extracts exhibited significant anti-hyperglycemic and anti-hyperlipidaemic effects on STZ induced diabetic rats when compared to that of standard drug (Glibenclamide 500μg / kg).

The present investigation of this plant established pharmacological evidence to support the folklore claim that it is an antidiabetic agent.