IgG, IgA and IgE reactivities to sperm antigens in infertile women
Joint Authors
Brazdova, Andrea
Zidkova, Jarmila
Peltre, Gabriel
Ulcova Gallova, Zdena
Source
Jordan Journal of Biological Sciences
Issue
Vol. 5, Issue 2 (30 Jun. 2012), pp.85-89, 5 p.
Publisher
The Hashemite University Deanship of Academic Research and Graduate
Publication Date
2012-06-30
Country of Publication
Jordan
No. of Pages
5
Main Subjects
Topics
Abstract EN
Nowadays, World Health Organization (WHO) appoints infertility as a disease.
Still more couples are diagnosed with unexplained infertility, it reaches almost 20 % of all cases.
Immune system plays an important role : iso-immunization of women is possible by human sperm cells.
For better understanding, it is necessary to detect and characterize antigens recognized by women immune system.
Our study is focused on female infertility and is based on the ejaculate sample from four healthy donors.
Antigens analyzed by sodium dodecyl sulphate polyacrylamide gel electrophoresis and isoelectric focusing (followed by IgG, IgA and IgE immunoblotting) were detected by forty-five sera from women who were diagnosed with fertility failure.
Ten children’s sera were used as negative controls.
The immunodominant sperm antigens detected by IgG antibodies were 68 and 123 kDa proteins with pI from 6.60 to 6.62, respectively.
Concerning mucosal immunity the most frequently recognized sperm IgA-binding protein reached 130 kDa and pI 6.9, 7.4, 9.5.
This study did not prove the association of IgE antibodies with unexplained infertility in women.
American Psychological Association (APA)
Brazdova, Andrea& Zidkova, Jarmila& Peltre, Gabriel& Ulcova Gallova, Zdena. 2012. IgG, IgA and IgE reactivities to sperm antigens in infertile women. Jordan Journal of Biological Sciences،Vol. 5, no. 2, pp.85-89.
https://search.emarefa.net/detail/BIM-311179
Modern Language Association (MLA)
Brazdova, Andrea…[et al.]. IgG, IgA and IgE reactivities to sperm antigens in infertile women. Jordan Journal of Biological Sciences Vol. 5, no. 2 (Jun. 2012), pp.85-89.
https://search.emarefa.net/detail/BIM-311179
American Medical Association (AMA)
Brazdova, Andrea& Zidkova, Jarmila& Peltre, Gabriel& Ulcova Gallova, Zdena. IgG, IgA and IgE reactivities to sperm antigens in infertile women. Jordan Journal of Biological Sciences. 2012. Vol. 5, no. 2, pp.85-89.
https://search.emarefa.net/detail/BIM-311179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 88-89
Record ID
BIM-311179