Role of melatonin and or vitamin B complex against hormonal changes in epinephrine-stressed rats

Abstract EN

The current study aimed to investigate uie cfila of inaamuscular injection of melatonin (MT) (lrrig / 'kg) "and / or vitarnhrB-complex (Tri-B) (20 mg / kg) on the hormonal changes induced by Epinephrine (Epi) (0.02 mg/kg) in male albino rats.

Intramuscular administration of Epi induced significant elevations in adrenocorticotropic hormone (ACTH), corticosterone (CORT), triiodothyronine (T3 ) and thyroxine (T4) levels after the two experimental durations.

On the other hand, luetinizing hormone (LH), testosterone, prolactin (PRL) and growth hormone (GH) levels were decreased under the same conditions.

Melatonin treatment seems to constitute a selection therapy, by improving ATCH, CORT, T3, T4 and GH levels but has no effect on the low levels of LH, testosterone and PRL.

Also, the data suggested that Tri-B injection partially improved the different endocrinological changes of Epi.