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Formulation and evaluation of asymmetric membrane mediated osmotic drug delivery system of gliclazide by applying taguchi’s L-8 design
Other Title(s)
صياغة و تقييم الأغشية غير المتناظر التناضحية في نظام تسليم الأدوية Gliclazide من خلال تطبيق تصميم تاجوشى ل L-8
Joint Authors
Dinesh, Puri
Vivek, Bhatele
Sunny, Sethi
Moon R. S.
Source
Jordan Journal of Pharmaceutical Sciences
Issue
Vol. 5, Issue 3 (30 Sep. 2012), pp.171-193, 23 p.
Publisher
University of Jordan Deanship of Academic Research (DAR)
Publication Date
2012-09-30
Country of Publication
Jordan
No. of Pages
23
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract AR
تهدف هذه الدراسة لوضع نظام لتقديم الأدوية التناضحي ل Gliclazide غير المتماثلة باستخدام تكنولوجيا الأغشية (AMT).
ففي هذه الدراسة, تم وضع أقراص باستخدام إيثيل السليلوز و الشيتوزان كغشاء غير متماثل لتشكيل البوليمرات.
و تم التأكد من الطبيعة غير المتكافئة للغشاء بواسطة المجهر الإلكتروني.
تم تقييم أقراص لمعلمات مختلفة مثل متوسط الوزن، و الصلابة، و تفتيت.
لوحظ أن مستوى osmogen, و مستوى طلاء البوليمر و مستوى المسام السابق في صياغة AM عوامل هامة في تصميم ل AMT التناضحي.
و لكن مستوى الملدنات لم يكن له أي تأثر على النتائج الصياغة.
Abstract EN
The purpose of the present study was to develop an osmotic drug delivery system for a Gliclazide by using asymmetric membrane technology (AMT).
In the study, the tablets were formulated by using ethyl cellulose and chitosan as asymmetric membrane forming polymers.
The asymmetric nature of the membrane coat was confirmed by scanning electron microscopy.
The tablets were evaluated for various parameters like average weight, hardness, friability, and assay and drug release.
A zero order release was achieved in dissolution study and it was established that the release rates were unaffected by the pH of the medium and the speed of agitation.
The ethyl cellulose coated AMT delivered the drug in an efficient zero order for about 20 hrs without any pharmacopoeia non-compliance.
It was also observed that the level of cosmogony, level of coating polymer and the level of pore former in the AM formulation emerged as the significant factors in the designing of an osmotic AMT.
The level of plasticizer and the quenching time however did not have any effect on the formulation outcomes.
The chitosan AMT delivered the drug gliclazide in a sustained manner for about eight hours.
The results showed that the actual and predicted values of the optimized formulation, according to the desired response, are near and the Taguchi design can successfully predict the best conditions for fabricating the Gliclazide AMT for modified drug delivery.
American Psychological Association (APA)
Dinesh, Puri& Vivek, Bhatele& Sunny, Sethi& Moon R. S.. 2012. Formulation and evaluation of asymmetric membrane mediated osmotic drug delivery system of gliclazide by applying taguchi’s L-8 design. Jordan Journal of Pharmaceutical Sciences،Vol. 5, no. 3, pp.171-193.
https://search.emarefa.net/detail/BIM-311531
Modern Language Association (MLA)
Dinesh, Puri…[et al.]. Formulation and evaluation of asymmetric membrane mediated osmotic drug delivery system of gliclazide by applying taguchi’s L-8 design. Jordan Journal of Pharmaceutical Sciences Vol. 5, no. 3 (2012), pp.171-193.
https://search.emarefa.net/detail/BIM-311531
American Medical Association (AMA)
Dinesh, Puri& Vivek, Bhatele& Sunny, Sethi& Moon R. S.. Formulation and evaluation of asymmetric membrane mediated osmotic drug delivery system of gliclazide by applying taguchi’s L-8 design. Jordan Journal of Pharmaceutical Sciences. 2012. Vol. 5, no. 3, pp.171-193.
https://search.emarefa.net/detail/BIM-311531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 191-192
Record ID
BIM-311531