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Effect of pentoxifylline administration on mast cell numbers and degranulation in a diabetic and normoglycemic rat model wound healing
Joint Authors
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 8 (31 Aug. 2012), pp.483-487, 5 p.
Publisher
Publication Date
2012-08-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Abstract EN
Background : wound healing is a complicated and integrated process.
Researches in the molecular level on human and animal models have indicated several molecular changes related to the effect of diabetes on wound healing process.
Objectives : increasing number of researches implicates the influence of mast cells on skin wound repairing.
In this study the effect of systemic pentoxifylline (PTX) administration (daily dose of 25mg / kg twice a day, for 7 consecutive days) on norm glycemic (NG) and diabetic (DB) wistar rat’s wound healing by secondary intention was studied.
Materials and Methods : in this study forty eight wistar rats (weighting 250-350g) were divided randomly in two groups : Norm glycemic and diabetic, each group was divided into experimental and control groups, experimental received intraperitoneal (PTX) and controls received distilled water(DW).
The number and maturing process of mast cells was evaluated by counting the number of types of mast cells (1, 2, 3) microscopically and by stereological methods on day 3 and 7 after surgery.
Results : in this study it was cleared that in wound healing process PTX caused increasing the number of type 2 mast cells in all experimental groups(P = 0.00).
In norm glycemic experimental group, receiving PTX there was decrease in the number of type3 mast cells, comparing experimental NG groups (P = 0.00).
Conclusions : in all PTX treated groups delay in converting type 2 into type 3 mast cell was seen.
Pentoxifylline causes decreasing mast cell degranulation in wound healing process.
American Psychological Association (APA)
Babaei, Saeid& Bayat, Muhammad. 2012. Effect of pentoxifylline administration on mast cell numbers and degranulation in a diabetic and normoglycemic rat model wound healing. Iranian Red Crescent Medical Journal،Vol. 14, no. 8, pp.483-487.
https://search.emarefa.net/detail/BIM-311658
Modern Language Association (MLA)
Babaei, Saeid& Bayat, Muhammad. Effect of pentoxifylline administration on mast cell numbers and degranulation in a diabetic and normoglycemic rat model wound healing. Iranian Red Crescent Medical Journal Vol. 14, no. 8 (Aug. 2012), pp.483-487.
https://search.emarefa.net/detail/BIM-311658
American Medical Association (AMA)
Babaei, Saeid& Bayat, Muhammad. Effect of pentoxifylline administration on mast cell numbers and degranulation in a diabetic and normoglycemic rat model wound healing. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 8, pp.483-487.
https://search.emarefa.net/detail/BIM-311658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 486-487
Record ID
BIM-311658