Prevalence of hepatitis B and C infections and HCV genotypes among haemophilia patients in ahvaz, South West Iran
Joint Authors
Zandian, Khamorad
Boroujerdnia, Mehri Ghafourian
Assarehzadegan, Muhammad Ali
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 8 (31 Aug. 2012), pp.470-474, 5 p.
Publisher
Publication Date
2012-08-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : transfusion-transmitted hepatitis is the most important cause of transmitted infections by the parenteral route in patients with hemophilia.
Objectives : this study was performed to determine the prevalence of HBV, HCV, and different genotypes of HCV among hemophilia patients in Ahvaz city, southwest Iran Patients and Methods : A cross-sectional study was conducted on 87 hemophiliac patients referred to the Hemoglobinopathy and Thalassemia research centre during February 2008 to March 2009.
Patients, sera were tested for HBsAg and anti-HCV using ELISA and confirmed by PCR (HBV) and RT-PCR (HCV).
HCV genotypes were determined with HCV genotype specific primers using HCV genotyping kit.
Results : the overall prevalence rate of HBsAg and anti-HCV were 1.1 % (95 % CI : 0-3.39) and 54 % (95 % CI: 43.5-64.4), respectively.
Forty two of the anti-HCV patients (89.3 %) were also HCV RNA positive.
The prevalence of anti-HCV Seropositivity was significantly higher (P = 0.0008) among patients who had started to receive transfusions before implementation of blood donor screening.
Moreover, the number of transfusion were significantly associated with anti-HCV and HCV RNA positivity (P = 0.0041 and P = 0.023, respectively).
The predominant HCV genotype among hemophiliac patients in our region was 1a (26 / 42, 61.9 %), although genotypes 1b and 3a were found in 26.1 % (11 / 42) and 11.9% (5 / 42) of the patients, respectively.
Conclusions : it appears stringent donor selection procedures reduced HCV infection in multi-transfused patients, but it is still serious risk for these subjects.
American Psychological Association (APA)
Assarehzadegan, Muhammad Ali& Boroujerdnia, Mehri Ghafourian& Zandian, Khamorad. 2012. Prevalence of hepatitis B and C infections and HCV genotypes among haemophilia patients in ahvaz, South West Iran. Iranian Red Crescent Medical Journal،Vol. 14, no. 8, pp.470-474.
https://search.emarefa.net/detail/BIM-311659
Modern Language Association (MLA)
Assarehzadegan, Muhammad Ali…[et al.]. Prevalence of hepatitis B and C infections and HCV genotypes among haemophilia patients in ahvaz, South West Iran. Iranian Red Crescent Medical Journal Vol. 14, no. 8 (Aug. 2012), pp.470-474.
https://search.emarefa.net/detail/BIM-311659
American Medical Association (AMA)
Assarehzadegan, Muhammad Ali& Boroujerdnia, Mehri Ghafourian& Zandian, Khamorad. Prevalence of hepatitis B and C infections and HCV genotypes among haemophilia patients in ahvaz, South West Iran. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 8, pp.470-474.
https://search.emarefa.net/detail/BIM-311659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 473-474
Record ID
BIM-311659