Investigate the role of glutathione S transferase (GST)‎ polymorphism in development of hypertension in UAE population

Abstract EN

Background : GST is a family of enzymes that are important in protection of the body against oxidative stress.

Objectives : investigate the association between GSTT1 and GSTM1 polymorphism and hypertension.

Materials and Methods : GSTT1 and GSTM1 genotypes were detected by PCR.

The fragments were then analyzed by agarose gel electrophoresis.

Results : there is no significant association between GSTT1 & GSTM1 polymorphism and hypertension (OR = 2.4, P > 0.05 and OR = 1.6, P > 0.05).

Conclusions : GSTT1 & GSTM1 polymorphism can be considered a risk factor for hypertension.