Biological activity of carica papaya grown in Jordan
Dissertant
Thesis advisor
al-Khatib, Iqbal
Muhaydat, Nizar M.
University
Al-Ahliyya Amman University
Faculty
Faculty of Pharmacy and Medical Sciences
Department
Pharmaceutical Sciences
University Country
Jordan
Degree
Master
Degree Date
2012
English Abstract
Carica papaya (Caricaceae) blown as paw or papaw, originally derived from the southern Mexico and Australia.
It is presently distributed over the whole tropical area.
In Jordan it is cultivated in AlGhoor.
Various parts of Carica papaya have been traditionally used as ethno medicine for a number of disorders, including psoriasis, ringworm, warts, tumors, corns and many other uses.
The goal of this study is to examine the effect of the total extract of Carica papaya leaves, seeds and fruit on the growth of various tumor cell lines in addition to antioxidant activity of leaves extract.
Papaya plant parts (leaves, seeds, ripe and unripe fruit) subjected for extraction by different polarity of solvents (chloroform, methanol and ethanol).
Furthermore, the plant extract was subjected to column chromatography and preparative TLC.
Followed by identification for compounds by various methods of chromatography (TLC, HPI.C) and chemical reagent.
The biological activity was carried to estimate the antitumor activity.
The acute cytotoxic effect of the extracts on human cancer cell lines was determined using MTT assays by using human melanoma (MV3, C32), breast (MDA-MB-486, MCF7), and colorectal (SW480, HCT116).
The evaluation of antioxidant activity of leaves methanol extract was done by DPPH free radical scavenging method.
Plant extracts induced variable degrees of cytotoxicity against cancer cell lines due to their active constituents which were observed in different parts of the plant in addition to antioxidant activity of leaves.
This is the first results belong to Carica papaya which cultivated in Jordan under different environmental conditions.
Main Subjects
Topics
American Psychological Association (APA)
al-Kit, Samar Ahmad M.. (2012). Biological activity of carica papaya grown in Jordan. (Master's theses Theses and Dissertations Master). Al-Ahliyya Amman University, Jordan
https://search.emarefa.net/detail/BIM-311669
Modern Language Association (MLA)
al-Kit, Samar Ahmad M.. Biological activity of carica papaya grown in Jordan. (Master's theses Theses and Dissertations Master). Al-Ahliyya Amman University. (2012).
https://search.emarefa.net/detail/BIM-311669
American Medical Association (AMA)
al-Kit, Samar Ahmad M.. (2012). Biological activity of carica papaya grown in Jordan. (Master's theses Theses and Dissertations Master). Al-Ahliyya Amman University, Jordan
https://search.emarefa.net/detail/BIM-311669
Language
English
Data Type
Arab Theses
Record ID
BIM-311669