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Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma
Joint Authors
Khalatbary, A. R.
Zarrinjoei, Gh. R.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 4 (30 Apr. 2012), pp.229-234, 6 p.
Publisher
Publication Date
2012-04-30
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background: Spinal cord injury stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue.
The purpose of this study was to determine the anti-inflammatory effect of oleuropein on traumatized spinal cord.
Methods: Rats were randomly divided into four groups of 7 rats each as follows: Sham-operated group, trauma group, and oleuropein treatment groups (20 mg/kg, ip, immediately and 1 hour after spinal cord injury).
Spinal cord samples were taken 24 hours after injury and studied for immunohistochemistry of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), nitrotyrosine, inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and poly(ADP-ribose) polymerase (PARP).
Results: Attenuated TNF-α, IL-1β, nitrotyrosine, iNOS, COX-2, and PARP expression could be detected in the oleuropein-treated rats.
Conclusion: Oleuropein modulates inflammatory reactions following spinal cord injury.
American Psychological Association (APA)
Khalatbary, A. R.& Zarrinjoei, Gh. R.. 2012. Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma. Iranian Red Crescent Medical Journal،Vol. 14, no. 4, pp.229-234.
https://search.emarefa.net/detail/BIM-311726
Modern Language Association (MLA)
Khalatbary, A. R.& Zarrinjoei, Gh. R.. Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma. Iranian Red Crescent Medical Journal Vol. 14, no. 4 (Apr. 2012), pp.229-234.
https://search.emarefa.net/detail/BIM-311726
American Medical Association (AMA)
Khalatbary, A. R.& Zarrinjoei, Gh. R.. Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 4, pp.229-234.
https://search.emarefa.net/detail/BIM-311726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 233-234
Record ID
BIM-311726